ID A0A6N6MPV6_9HYPH Unreviewed; 740 AA.
AC A0A6N6MPV6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=ATP-dependent RecD2 DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=5.6.2.3 {ECO:0000256|HAMAP-Rule:MF_01488};
DE AltName: Full=DNA 5'-3' helicase subunit RecD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=F6X51_13735 {ECO:0000313|EMBL:KAB1073035.1};
OS Methylobacterium planeticum.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=2615211 {ECO:0000313|EMBL:KAB1073035.1, ECO:0000313|Proteomes:UP000441523};
RN [1] {ECO:0000313|EMBL:KAB1073035.1, ECO:0000313|Proteomes:UP000441523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 132548 {ECO:0000313|EMBL:KAB1073035.1,
RC ECO:0000313|Proteomes:UP000441523};
RA Jiang L.;
RT "YIM 132548 draft genome.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB1073035.1}.
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DR EMBL; VZZJ01000010; KAB1073035.1; -; Genomic_DNA.
DR RefSeq; WP_150964225.1; NZ_VZZJ01000010.1.
DR AlphaFoldDB; A0A6N6MPV6; -.
DR Proteomes; UP000441523; Unassembled WGS sequence.
DR GO; GO:0009338; C:exodeoxyribonuclease V complex; IEA:TreeGrafter.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IEA:TreeGrafter.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD2; 1.
DR InterPro; IPR050534; Coronavir_polyprotein_1ab.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006345; RecD2.
DR InterPro; IPR029493; RecD2-like_HHH.
DR InterPro; IPR055446; RecD2_N_OB.
DR InterPro; IPR041451; RecD2_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788:SF6; DNA HELICASE B; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF14490; HHH_RecD2; 1.
DR Pfam; PF23139; OB_YrrC; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:KAB1073035.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000441523}.
FT DOMAIN 98..119
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 133..152
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 197..216
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT BINDING 361..365
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 740 AA; 80734 MW; A3EB1E953D8B9117 CRC64;
MNRMVRPGEF HPEAPADVLA GTVERVTFHN AETGFCVLKV AVRGRRDLVP LVGHAPAIGA
GEWITATGHW ITDRAHGLQF KAETLKATPP TGIEGIERYL ASGQMRGIGP AMAKAIVALF
GAGTFEIIEA TPGRLMEVPG IGKKRAERIV RGWAEQKAVR EIMIFLHAHG VGTARAVRIF
RTYGHDAIGV MTEDPYRLAR DIRGIGFRTA DAIAMRLGLD RYAPQRLNAG IAFALQTAMD
EGHCGLPAER LTGLAVKLLD VDAEAVRLAT AVTLRAGDTV IADELDGEPC LFLKGLHGAE
RSIAERLLLR AAGPPPWEAI DLDKALPWVE GRTHKTLSPS QVEAVRLVLG SRLCVVTGGP
GVGKTSTLDS ILRILTANCV RVILAAPTGR AAKRMSEQTG LEARTIHRLL EIDPRNGGFS
RNAENPLDCD LLVIDETSMV DVPLMNALLK ALPEPAGLLL VGDVDQLPSV GPGQVLGDII
ASGQIAVARL TEVFRQAAES RIVVNAHRIN RGEMPEWPKR GAESDFYCVE IDDPDDGVAK
LVEVVTQRIP KRFGLDPIRD VQVLTPMIRG SLGARNLNQE LQRVLNPDPP AQVERFGWRF
APGDRVMETQ NDYDRDVFNG DLGRVTGIDP EEGLLIVDFD GRAVTYPFAE LDTLVPAFAT
TIHKSQGSEY PAVVIPVTTQ HWTMLARNLL YTGVTRGRSL VVLIGQRKAI AMAVRGTRTR
RRWTKLRRWL EAGRGDLRLQ
//
