ID A0A6N7QUV3_9BACI Unreviewed; 548 AA.
AC A0A6N7QUV3;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=dcuS {ECO:0000313|EMBL:MRI64731.1};
GN ORFNames=GH885_00025 {ECO:0000313|EMBL:MRI64731.1};
OS Gracilibacillus thailandensis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Gracilibacillus.
OX NCBI_TaxID=563735 {ECO:0000313|EMBL:MRI64731.1, ECO:0000313|Proteomes:UP000435187};
RN [1] {ECO:0000313|EMBL:MRI64731.1, ECO:0000313|Proteomes:UP000435187}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TP2-8 {ECO:0000313|EMBL:MRI64731.1,
RC ECO:0000313|Proteomes:UP000435187};
RA Gan L.;
RT "Gracilibacillus salitolerans sp. nov., a moderate halophile isolated from
RT a saline soil in northwest China.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MRI64731.1}.
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DR EMBL; WJEE01000001; MRI64731.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6N7QUV3; -.
DR Proteomes; UP000435187; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR FunFam; 1.10.287.130:FF:000011; Sensor histidine kinase DcuS; 1.
DR FunFam; 3.30.450.20:FF:000018; Sensor histidine kinase DcuS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR InterPro; IPR039506; SPOB_a.
DR NCBIfam; NF008298; PRK11086.1; 1.
DR PANTHER; PTHR43547:SF10; SENSOR HISTIDINE KINASE DCUS; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF14689; SPOB_a; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF55890; Sporulation response regulatory protein Spo0B; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:MRI64731.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000435187};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:MRI64731.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..539
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 548 AA; 60738 MW; CFBEBD99036AA8EB CRC64;
MSAIILNIKW GDVVKRPFKL SVIITLFGCI VVLLSLLVTD LLISNTTSER IRDNQEEKAQ
IVSRTVAKSE IVKASLLQKE KTEAIQAYTQ EVQTITEMMF VVVMDIEGIR YTHPNPEMIG
EYFKGGDEKA VLQGEEYVSV SEGTLGDSLR SFTPIYDDNG NQIGAVAVGI SLDNVEFALS
QGHQNIMKGS LLGIIVGIIG AFLLAKYIKR MLFGLEPYQI SKLLEERSTM LQSVHEGILA
VDDDLRITLV NKSALHLFKK AGLSDQPIGM KITDYMPNTK LDRVIETGES ERNEEQTLNG
ISILTNREPL IVNNKVVGAI STFRDKTEVN QLAKQLTGVR TYVEALRAQS HEFMNRLHVI
LGMVQMGAYD ELLPFIRKII DMNNQEAAVI TKTIKDPVLA GFLIGKMSYA RERNVTFKIS
NDSRIDEALS LETSQELITI IGNLVDNAIE ALTTSVEKKI ALQLKKNHGK LSITVSDSGP
GISAENTEKI FKKGFSSKGS NRGFGLYLMN QSIEKLNGEL KMSTNKRGTT FNVVLDYAAM
RDGMQDGD
//
