ID A0A6N9TSH3_DISTH Unreviewed; 646 AA.
AC A0A6N9TSH3;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:NDY43043.1};
GN ORFNames=G3N55_09335 {ECO:0000313|EMBL:NDY43043.1};
OS Dissulfurirhabdus thermomarina.
OC Bacteria; Deltaproteobacteria; Dissulfurirhabdaceae; Dissulfurirhabdus.
OX NCBI_TaxID=1765737 {ECO:0000313|EMBL:NDY43043.1, ECO:0000313|Proteomes:UP000469346};
RN [1] {ECO:0000313|EMBL:NDY43043.1, ECO:0000313|Proteomes:UP000469346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100025 {ECO:0000313|EMBL:NDY43043.1,
RC ECO:0000313|Proteomes:UP000469346};
RA Ward L.M., Bertran E., Johnston D.T.;
RT "Comparative genomics of sulfur disproportionating microorganisms.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NDY43043.1}.
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DR EMBL; JAAGRR010000113; NDY43043.1; -; Genomic_DNA.
DR RefSeq; WP_163299163.1; NZ_JAAGRR010000113.1.
DR AlphaFoldDB; A0A6N9TSH3; -.
DR Proteomes; UP000469346; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:NDY43043.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000469346}.
FT DOMAIN 9..182
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 646 AA; 71411 MW; 7811C57E6F11ED49 CRC64;
MDRTDIPRQQ TVILGTAGHI DHGKTTLVRA LTGIDTDRLK EEKERGITIE LGFAHLTLPD
GRRIGVVDVP GHERFVKNMV AGAMGVDLVA LVVAADEGVM PQTREHLEIT QLLGVRKGLV
VLTKIDLVDR DWLELVTEDV REYLSGTFLA DAPIVPVSSV TGEGLDALRA RLAELVAEVE
PRIPAGPYRL PVDRVFTVKG FGTVVTGTTV SGRIRVGDEA VVYPRGLETR IRGIQVHGAE
AGEALAGLRT ALNLQGLEKG DLARGDVVAT PGSLHPTYLL DLEFHHLASA ARPLKYRSPV
RFHVGTAEVI GRVLFQGDEL EPGTDALIQV QLEAPVAALR GDRYVIRSYS PVHTIGGGRI
LNPLPRRRKR TRPEHWAELE RLARADAGDL IAYHLEKAGL RGLTEAELAM RTGLYGKTLH
RELERLLGAR RVVRHEGEGR RLLDGGLYED LKRRATEFLA RYHEANPLQA GAPKEELRSR
LMPGDGGGRI FQRLLSDLAR SGDVVLERDR VRLPGHQVAL GKEEAAFRDR IEVLFRKAGL
QPPSRAEVVG KFPGKEEAAA RVFDLLVREG VLVHLREGLC IHREALEQAR ELVVRHLREK
GELSVTDFRE LTGGLSRKYM IPLLEYLDNQ KVTLRVGDVR RLRSGA
//
