ID   A0A6P3WF76_CLUHA        Unreviewed;       342 AA.
AC   A0A6P3WF76;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   28-JAN-2026, entry version 23.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   Name=bbs5 {ECO:0000313|RefSeq:XP_012697096.1};
OS   Clupea harengus (Atlantic herring).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC   Clupeidae; Clupea.
OX   NCBI_TaxID=7950 {ECO:0000313|Proteomes:UP000515152, ECO:0000313|RefSeq:XP_012697096.1};
RN   [1] {ECO:0000313|RefSeq:XP_012697096.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
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DR   RefSeq; XP_012697096.1; XM_012841642.3.
DR   AlphaFoldDB; A0A6P3WF76; -.
DR   GeneID; 105912659; -.
DR   KEGG; char:105912659; -.
DR   CTD; 129880; -.
DR   OrthoDB; 10261999at2759; -.
DR   Proteomes; UP000515152; Chromosome 2.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0062139; P:camera-type eye photoreceptor cell development; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0070121; P:Kupffer's vesicle development; IEA:Ensembl.
DR   GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR   GO; GO:0051877; P:pigment granule aggregation in cell center; IEA:Ensembl.
DR   GO; GO:0072116; P:pronephros formation; IEA:Ensembl.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515152}.
FT   DOMAIN          29..83
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          159..213
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   342 AA;  38967 MW;  437793C0E4DD466F CRC64;
     MASVLDVLWE DRDVRFDIST QQMKTRPGEV LIDCLDSIED TKGNNGDRGR LLVTNLRIIW
     HSLALPRVNL SVGYNTIINI TTRTANSKLR GQTEALYILT KSNNTRFEFI FTNVVPGSPR
     LFTSVIAVHR AYETSKMYRD LKLRGALIQN KQLRLLPREQ VYDKINGVWN LSSDQGNLGT
     FFITNVRIVW HANMNESFNV SIPYLQIRSI RIRDSKFGLA LVIESSQQTG GYVLGFKIDP
     MDKLQDAVKE INSLHKVYSA NPIFGVEYEM EEKPQPLEDL TVDQPPDDVE IEPDEQTDAF
     TAYFADGNKQ QDREPVFSEE LGLAIEKLKD GFTLQGLWEV MG
//