ID   A0A6P4HQU6_DROKI        Unreviewed;       511 AA.
AC   A0A6P4HQU6;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   18-JUN-2025, entry version 21.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   Name=LOC108071897 {ECO:0000313|RefSeq:XP_017018316.1,
GN   ECO:0000313|RefSeq:XP_017018317.1};
OS   Drosophila kikkawai (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=30033 {ECO:0000313|Proteomes:UP000515200, ECO:0000313|RefSeq:XP_017018317.1};
RN   [1] {ECO:0000313|RefSeq:XP_017018316.1, ECO:0000313|RefSeq:XP_017018317.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC       {ECO:0000256|ARBA:ARBA00005884}.
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DR   RefSeq; XP_017018316.1; XM_017162827.1.
DR   RefSeq; XP_017018317.1; XM_017162828.1.
DR   EnsemblMetazoa; XM_017162827.2; XP_017018316.1; LOC108071897.
DR   EnsemblMetazoa; XM_017162828.2; XP_017018317.1; LOC108071897.
DR   GeneID; 108071897; -.
DR   OrthoDB; 10009520at2759; -.
DR   Proteomes; UP000515200; Unplaced.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR   FunFam; 1.20.120.1750:FF:000002; RBR-type E3 ubiquitin transferase; 1.
DR   FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045840; Ariadne.
DR   InterPro; IPR048962; ARIH1-like_UBL.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF19422; Ariadne; 1.
DR   Pfam; PF01485; IBR; 1.
DR   Pfam; PF22191; IBR_1; 1.
DR   Pfam; PF21235; UBA_ARI1; 1.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515200};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          134..342
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  59805 MW;  12689E5C5A87D876 CRC64;
     MSSNDKTEAS PSFIGNESPS QPIAGNWDSE EETDIVSPET PCQHVEPDDF VYKVLSVYQI
     VQHQRDIIDE VNNVLNLSPP VARTILNHFN WDKERLLENY FESTPHEFFQ RAQVLNPFEI
     DIPSPPEAYN PSLDDLACEI CFCSDLEHFG LGCGHNYCVE CWKQYLVNKT CSEGLTHTIT
     CPAANCNILV DYATYLALVD DLKVVERYKQ LTANTFVKCN TLMRWCPAPN CSYVIEANYM
     GPKAVECKCG HQFCFSCGEN WHEPVACNLL KNWLSIIEDP ETTNWIYHNT KKCPQCQVSI
     QKFGGCEHMV CRNLSCLYQF CWLCLQPWRW HSLDWFRCRL FAEAAERRAR LEQENSSDTR
     VRVQYYKDCY ISHMQSMKKE RKLYAEIQAK INDKELGIRW IEVQFLRDAI DAMCQCRSIL
     MYSYVFAFYL KNNNQKEIFE YNQKDLETAT DRISECLQQE ITVENLYDIK KKVIELSQYC
     QQRRHVLLSY VREGNEKGWW DCKEATLPSP F
//