ID A0A6P5LK44_PHACI Unreviewed; 539 AA.
AC A0A6P5LK44;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_020856905.1, ECO:0000313|RefSeq:XP_020856906.1};
GN Name=SOCS5 {ECO:0000313|RefSeq:XP_020856905.1,
GN ECO:0000313|RefSeq:XP_020856906.1, ECO:0000313|RefSeq:XP_020856907.1,
GN ECO:0000313|RefSeq:XP_020856908.1, ECO:0000313|RefSeq:XP_020856909.1};
OS Phascolarctos cinereus (Koala).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Phascolarctidae; Phascolarctos.
OX NCBI_TaxID=38626 {ECO:0000313|Proteomes:UP000515140, ECO:0000313|RefSeq:XP_020856909.1};
RN [1] {ECO:0000313|RefSeq:XP_020856905.1, ECO:0000313|RefSeq:XP_020856906.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_020856905.1,
RC ECO:0000313|RefSeq:XP_020856906.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_020856905.1; XM_021001246.1.
DR RefSeq; XP_020856906.1; XM_021001247.1.
DR RefSeq; XP_020856907.1; XM_021001248.1.
DR RefSeq; XP_020856908.1; XM_021001249.1.
DR RefSeq; XP_020856909.1; XM_021001250.1.
DR AlphaFoldDB; A0A6P5LK44; -.
DR GeneID; 110218504; -.
DR KEGG; pcw:110218504; -.
DR CTD; 9655; -.
DR GeneTree; ENSGT00940000159000; -.
DR OMA; CQNLFNH; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515140; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0097699; P:vascular endothelial cell response to fluid shear stress; IEA:Ensembl.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000515140};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 384..479
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 474..523
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 116..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 61620 MW; A3E3C3F6091A5D2F CRC64;
MDKVGKMWNN FKYRCQNLFN HEGGNNSENI DVNSNRCLSV KERNMSIGDL APQQQSSPLR
ENVALQLELS PSKNSSRRNQ NCATEIPQIV EISIEKENDS CVPTTGARLA RRDSYSRHAP
WGGKKKHSCS TKTQSSLDTE KRFGRTRSGL QRRERRYGVS SVHDMESVSS RTVGSRSLRQ
RLQDTVGLCF PMRTYNKQAK PLFSNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
VSPHSTFFDT FDPSLVSTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPLYKL
GPKLAPGMTD MTGENAAAPQ GSCDSEEDAT TLCLQARRQK QRQGSGDSHT HTHTGRQGAW
KVHTQIDYIH CLVPDLLQIT GNPCYWGVMD RYEAEALLEG KPEGTFLLRD SAQEDYLFSV
SFRRYNRSLH ARIEQWNHNF SFDAHDPCVF HSSTVTGLLE HYKDPSSCMF FEPLLTVSLN
RTFPFSLQYI CRAVICRCTT YDGIDGLPLP SMLQDFLKEY HYKQKVRVRW LEREPIKAK
//
