ID A0A6P5X6J7_DURZI Unreviewed; 756 AA.
AC A0A6P5X6J7;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=LOC111280304 {ECO:0000313|RefSeq:XP_022723277.1};
OS Durio zibethinus (Durian).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Helicteroideae; Durio.
OX NCBI_TaxID=66656 {ECO:0000313|Proteomes:UP000515121, ECO:0000313|RefSeq:XP_022723277.1};
RN [1] {ECO:0000313|RefSeq:XP_022723277.1}
RP IDENTIFICATION.
RC TISSUE=Fruit stalk {ECO:0000313|RefSeq:XP_022723277.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR RefSeq; XP_022723277.1; XM_022867542.1.
DR AlphaFoldDB; A0A6P5X6J7; -.
DR GeneID; 111280304; -.
DR Proteomes; UP000515121; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0031559; F:oxidosqualene cyclase activity; IEA:UniProtKB-ARBA.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR FunFam; 1.50.10.20:FF:000002; Terpene cyclase/mutase family member; 1.
DR FunFam; 1.50.10.20:FF:000022; Terpene cyclase/mutase family member; 1.
DR Gene3D; 1.50.10.20; -; 3.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11764:SF85; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000515121};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 103..400
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 417..749
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 756 AA; 86204 MW; 22A9905404B4CC8A CRC64;
MWRLKIGKET VGDSGGWLRS LNNHVGRQVW EFCPESGTPE ELSKVEVARQ SFRDHRFQKK
HSSDLLMRIQ FAKENKFVND LPQVKLNEFE DVKEEAIVTT LRRALNFYST IQSHDGHWPG
DYGGPMFLLP GLVITLYVTG ALNAVLSKEH QYEICRYLYN HQNRDGGWGL HIEGPSTMFG
TVLNYVSLRL LGEGADDGQG AVEKAREWIL EHGSATAITS WGKMWLSVLG AYEWSGNNPL
PPEVWLCPYF LPVHPGRMWC HCRMVYLPMS YLYGKRFVGP ITPTILSLRK ELYSVPYHEV
DWNKARNTCA KEDLYYPHPL VQDILWASLH YFYEPMFTHW PCKNLRKKAL HTVMQHIHYE
DENTRYICIG PVNKVLNMLC CWVEDPHSES FKLHLPRISD YLWIAEDGMK MQGYNGSQLW
DTAFALHAII STGLAEEYGS ILRKAHDFVL EDCPGDVNFW YRHISKGAWP FSTVDHGWPI
SDCTSEGLKA VLLLSTLPPV VVGEPLDVIR LYDAVNVVLS LQNVDGGFAT YELTRSYPWL
ELINPAESFG DIVIDYPYVE CTSAAIQALA SFKKLYPEHR TVEIENCICR GVEFIEKTQA
ADGSWYGSWG VCFTYAGWFG IKGLSAAGRT YINSSNIRKA CDFLLSKELA TGGWGESYLS
CQNKVYTNLE GNRPHIVNTS WAMLALIEAG QAERDPTPLH RAARILINSQ MEDGDFPQQE
IMGVFNKNCM ISYSAYRNIF PIWALGEYQC RVLQAP
//
