ID A0A6P6AQN0_DURZI Unreviewed; 3055 AA.
AC A0A6P6AQN0;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Serine/threonine-protein kinase ATM {ECO:0000256|ARBA:ARBA00073111};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC111311725 {ECO:0000313|RefSeq:XP_022767101.1};
OS Durio zibethinus (Durian).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Helicteroideae; Durio.
OX NCBI_TaxID=66656 {ECO:0000313|Proteomes:UP000515121, ECO:0000313|RefSeq:XP_022767101.1};
RN [1] {ECO:0000313|RefSeq:XP_022767101.1}
RP IDENTIFICATION.
RC TISSUE=Fruit stalk {ECO:0000313|RefSeq:XP_022767101.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048679};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047899};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022767101.1; XM_022911366.1.
DR GeneID; 111311725; -.
DR KEGG; dzi:111311725; -.
DR OrthoDB; 381190at2759; -.
DR Proteomes; UP000515121; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd05171; PIKKc_ATM; 1.
DR FunFam; 1.10.1070.11:FF:000015; Serine/threonine-protein kinase ATM; 1.
DR FunFam; 3.30.1010.10:FF:000023; Serine/threonine-protein kinase ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR057445; ATM_TPR.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF25360; TPR_ATM; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_022767101.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000515121};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1189..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1928..2592
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2698..3011
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3023..3055
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 2455..2482
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3055 AA; 347664 MW; FE9BA21F723F39A4 CRC64;
MVTSSDVQEI VSKLSSDKAK AREEGIKLLN MWLEGERSIG FCKFIGQNTA KLKPNEIPQS
ETWPFLIKLL TQCLSLEIST SKRRLPKLIF AKTLRIVIQR AEDTKFPGNM LPLLSVVKTL
FSHMLDVLNN VPSFQSEYGI ILRNLLAVRD YRFHMRKSIY SGFMVFYMEK VETTLSEKNN
SQYSQKEEIF RSILTLQSLL ENPPGDFPDN LREDIVKGFV KIFSYIRDEG KVSRKLIECI
NTYLLKDGPN LSCQSLEIHN ATQQFVFRFW LTTHDKGLKD ALVLYARLQL NLVRGVVDGS
FLVEQLLDVI CKELDQSNLS IPVTSWSDGA KDDKFGTLSS SQHNLVELAA LILYRACVNT
SRATLNEKRV KRESAAACLK DALMKGKWLW HVSFCYLIRN YYTRISKDLF VYWFEGICAS
FERILNDANV GHAYDGLLWT LRSLQELSSM LLLSDAQVEI SLSSSFTSKE FDCGWQLIWS
HLMHGLPTFS NVIPVVDAAL ALLGSIIAND LTNSCVVPHD VWDLRLFKGM PSLCSLYFIA
CYFSQKGSQG DLRDILHLRK YLLRATLGSL SWNESSLLNN RMVLLLPAAV YALCAGCEPF
TQCYKEILRL HSFVDAIEVA DDWIKIDEYD HERQLENFEC SVEVVANIDL DSNVQVSPSH
FHQSVSLPRQ LREPLMHEME TYILGVLADH NVEKKRLSDV FFICALLCNL IYGLYLTRNR
EEVSPFLSKL GHYLLELLND AINVILKNIN DSRSLGSLGF TSGFNPKTAI VASFKSFVLG
PLFTQRRDGD APDTVLYDAI KQSLQRLLKA FAKLYDEYIE SVTNHRSEMF SSDSSGSGSS
IQISNHVDSN KSRIMDMELD VNEDGKDVDI QTSSGNISTC GSFSAMKWKL GMVSLISSFF
SVVHNQTWDV LLNLMEKELD LKVYEIILCN LCRHLDSLSS SKLTDLVNLI KNRTRMQVSL
KLDSFNVLAA IGCLLDTLLS LEVGKDKHGA IALEEREAKQ SLTYLGELAS KVAEFELLDW
FGRIKLIDCI CNFILLSPVI GQPLYGAFLL FHNYLQTMIE KLLCMLQDPD YRVRFFLSRR
IGVLFQTWDG HGELFHDICS NFGMELVYYS KEKLVTAREV LAAGPQPRSK VETVIITLMQ
LALHSEKIEL EAVFMMCAVS AIDSCQRELV TAAFDNLSRK LQYISRMKYL EELIGSILFC
WVACGVSIAA LVEIRQLFVS DTEPSYFLQY CFRWLLPALL IHENNSNLNW VAKIAGQPLS
VIVMDHFVPI FSVCMTLYCS KSSGFEKGTM VLQNSILHLA EISENERDKL IKKNMVSIVG
HILSLASCAS DPLIPFFSRD TVACAIQTVV DGFLEMDDCC ASSSVIDKIN IFRPNRAFMF
IIEMHYKIAA AIHHRHRCHR LASVEVLIII LGHRAALSST SNYLFNLIGQ FIGCHALQDQ
CCRIISALLK TFKSNPSKEI VGVLGEQLQF LVSKLVACCI PLEADGQPSA SVSSQVLSLL
LELTVDSDPL LYDYIRELEP FPEIDIFEGI RNFHQDLCRA YSPRDHLLKF VKRSCYLPPR
LLSWSLQALH KKLLAGETFQ AGKSAKELVD DTYWYGDSEI VHAVWTLVRM CSSDDTSMIR
GLVSDFISRV GIGDPHSVVF HLPGDSNNMH VCGPISHSGS SEIIFSMDTG ISEELLIALL
KVLKKYLMDD SVKIVDITSQ TLQGILSTER GQKAMLSFDS YERSLIEVHS RGINFELVEK
LLMDLERKFK VITAEDIFLE KSTTWVTHGK TFEMWICPLV YSLVGYCNDV ILRLCQDIVL
LKPEVAELLL PSIVVNLAGR KDIDVDIQKL ISCQVQEHIF VESNKLIKSI QVWLNALNEL
RFCYVLERSS GPLKKEKKES SKHAKPSSYS SRSLFSMKTR DSAATLSAMA MSTSSWNKVY
WLSIDYLVAA RSAIICGSYF TSMMYVEYWC EEHFHSLTLG NPDFSNLEML PQHIEILILA
ITQINEPDSL YGIIQSHTLT SQIITFEHEG NWNKALEYYD LQVRLEATAH VDGSSRTLSL
AEIQSLSHSS LSTLEDETNR KPYKGLIRSL QQIGCRHVLD LYCQGLTSGR GQFQQDLEFT
ELQYEAAWRA GNWDFSLLYT GASSHSTGQH PKTHHFNENL HSCLRALQEG DSDEFQRKLK
HSKEELVWSV SHASEESTEF IYSTIIKFQI LYHLGIAWEI RWPTSSYERI KLQKHKKKMF
SDPIIPTMDQ LLWLNKDWSS MLTKSQLHMS LLEPFIAFRR VLLQILNCDN CTMQHLLQSA
STLRKGSRFS QAAAALHEFK FLCVGTGEQG STPYWLGRLE EAKLLRAQGQ HEMAIGLGKY
ILQTYQLNEE ASDVYRLVGK WLAETRSSSS RTIFEKYLKP AVSLAEGHKT ADKKTAERQS
QTHFHLAHYA DALFRSYEDR LNSNEWQAAM HLRKHKKLEL EALFRRLKGS TEGDKIDYSV
KIQELKKQLA MDEEEAQKLQ DDRDNFLSLA LEGYKCCLVI GDKYDVRVVF RLVSLWFSLS
SSQDVVNNLL KTIDEVQTYK FVPLVYQIAS RMGSLNGIVP NNFQFALVSL VKKMAIDHPY
HTIFQLLALA NGDRIKDKQR SRNSFVVDVD KKLAAENLLG ELSAYHGPVI RQMKQMVEIY
IKLAELETKR EDTSRKLPLP REIRSVRQLE LVPVLTASFP VDHSCQYREG SFPFFRGLAD
SVMVMNGVNV PKVVECLGSD GRKYKQLAKS GNDDLRQDAV MEQFFGLVNT FLQNHRDTWK
RRLVIRTYKV VPFTPSAGVI EWVDGTLPLG EYLTGSNRNG GAHGRYGIGD WSFLKCREHM
SNEKDKRKAF QEVCEKFRPV MHYFFLERFL QPADWFEKRL SYTRSVAATS MVGYIVGLGD
RHTMNILIDQ ATAEVVHIDL GVAFEQGLML KTPERVPFRL TRDIIDGMGV AGVEGIFRKC
CEETLSVMRT NKEALLTIIE VFIHDPLYKW ALSPLKALQR QKETDYDLES SLEGFQDEYE
GNKDAARALM RVKQKLDGYE EGEMRSVHGQ VQQLIQDAID PERLCQMFPG WGAWM
//
