ID A0A6P6BV91_PTEVA Unreviewed; 1224 AA.
AC A0A6P6BV91;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 10-JUN-2026, entry version 27.
DE SubName: Full=Helicase SKI2W isoform X2 {ECO:0000313|RefSeq:XP_023378860.1};
GN Name=SKIV2L {ECO:0000313|RefSeq:XP_023378860.1};
OS Pteropus vampyrus (Large flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea;
OC Pteropodidae; Pteropodinae; Pteropus.
OX NCBI_TaxID=132908 {ECO:0000313|Proteomes:UP000515202, ECO:0000313|RefSeq:XP_023378860.1};
RN [1] {ECO:0000313|RefSeq:XP_023378860.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_023378860.1};
RG RefSeq;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_023378860.1; XM_023523092.1.
DR AlphaFoldDB; A0A6P6BV91; -.
DR GeneID; 105305291; -.
DR CTD; 6499; -.
DR Proteomes; UP000515202; Unplaced.
DR GO; GO:0055087; C:Ski complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IEA:TreeGrafter.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000354; ATP-dependent RNA helicase SKI2; 1.
DR FunFam; 3.40.50.300:FF:000447; helicase SKI2W isoform X2; 1.
DR FunFam; 1.10.3380.30:FF:000005; Ski2 like RNA helicase; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_023378860.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000515202};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 319..475
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 585..755
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 130..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 135929 MW; DA3852828F0474CF CRC64;
MIETERLALP PPDPLDLPLR AVELGCTGRW EVLNAPGAPE STLPHGLPPC APDLQQEAEQ
SFLSSPAWLP LHGVEHSDRK WQRKMDPWSL LAILGAPVPS DLQAQRHPTT GQILGYKEVL
LENTDLSATT SLSLRRPPGP TSQSLWGNPT QYPFWPGGMD EPTMRDLSTQ EEAEEEIDFE
KDLLTIPPGF KKGMDFAPKD HPAPAPGLFS LSRLLEPLDL GGGDEFEREA VGQPGGTRED
SVSASPCSAP LARTSSLEDL VLKEASTVVS LPELSKPPPQ EQWAIPVDVT SPVGDFYRLI
PQPAFQWAFE PDVFQKQAIL HLERHDSVFV AAHTSAGKTV VAEYAIALAQ KHMTRTIYTS
PIKALSNQKF RDFRNTFGDV GLLTGDVQLH PEASCLIMTT EILRSMLYSG SDVIRDLEWV
IFDEVHYIND AERGVVWEEV LIMLPDHVSI ILLSATVPNA LEFADWIGRL KRRQIYVIST
VARPVPLEHY LFTGNSPKTQ GELFLLLDSR GTFHTKGYYA AVDAKKERMS KHAQTFGAKQ
PTHHGGPAQD RGVYLSLLAF LRTRAQLPVV VFTFSRGRCD EQASGLTSLD LTTSSEKSEI
HIFLQRCLAR LRGSDRQLPQ VLHMSELLHR GLGVHHSGIL PILKEIVEML FSRGLVKVLF
ATETFAMGVN MPARTVVFDS MRKHDGSTFR DLLPGEYVQM AGRAGRRGLD PTGTVILLCK
GRVPEMVDLH RMMMGKPSQL QSQFRLTYTM ILNLLRVDAL RVEDMMKRSF SEFPSRKDSK
AHEQSLAELT KKLGALEEPD VTGQLVDLLE YYRWGEELTE TRSLIQRRVL ESVNGLKSLS
AGRVVVVKNQ EHHNVLGVIL QVSSNSMSRV FTTLVLCDKP TSEDPQERGS ASPDVPYPDD
LIGFKLFLPE GPCDHTVAKL QTGDVAAITT KVLRVNGEKI LEDFSKRQLP KFKKDPPIAA
VTTAVQELLR LAQAYPAGPP TLDPVNDLQL KDVSVVEGEL RARKLEELIR GAQCVHSPRF
PTQYLKLRER MQIQKEMERL RFLLSDQSLL LLPEYHQRVE VLRILGYVDE AGTVKLAGRV
ACAMSSHELL LTELMFDNAL SALQPEEIAA LLSGLVCQSS GDTGEQLPST LKQGVERVRA
VAKRIGEVQV ACGLNQTVEE FVGELNFGLV EVVYEWARGM SPPCFPHSPS LSWQGSLGPL
KAWWSAASSA WLRCVARCGG QPAW
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