ID A0A6P6HS10_PUMCO Unreviewed; 1287 AA.
AC A0A6P6HS10;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 10-JUN-2026, entry version 24.
DE RecName: Full=Zinc finger transcription factor Trps1 {ECO:0000256|ARBA:ARBA00073694};
GN Name=TRPS1 {ECO:0000313|RefSeq:XP_025778590.1};
OS Puma concolor (Mountain lion) (Felis concolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma.
OX NCBI_TaxID=9696 {ECO:0000313|Proteomes:UP000515131, ECO:0000313|RefSeq:XP_025778590.1};
RN [1] {ECO:0000313|RefSeq:XP_025778590.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025778590.1};
RG RefSeq;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: Transcriptional repressor. Binds specifically to GATA
CC sequences and represses expression of GATA-regulated genes at selected
CC sites and stages in vertebrate development. Regulates chondrocyte
CC proliferation and differentiation. Executes multiple functions in
CC proliferating chondrocytes, expanding the region of distal
CC chondrocytes, activating proliferation in columnar cells and supporting
CC the differentiation of columnar into hypertrophic chondrocytes.
CC {ECO:0000256|ARBA:ARBA00058641}.
CC -!- SUBUNIT: Interacts with RNF4; regulates TRPS1 repressor activity.
CC Interacts specifically with the activator form of GLI3 (GLI3A) but not
CC with the repressor form (GLI3R). {ECO:0000256|ARBA:ARBA00066009}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025778590.1; XM_025922805.1.
DR GeneID; 112859537; -.
DR CTD; 7227; -.
DR Proteomes; UP000515131; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR GO; GO:0001501; P:skeletal system development; IEA:UniProtKB-ARBA.
DR CDD; cd00202; ZnF_GATA; 1.
DR FunFam; 3.30.160.60:FF:001213; Transcriptional repressor GATA binding 1; 1.
DR FunFam; 3.30.50.10:FF:000020; Zinc finger transcription factor Trps1; 1.
DR FunFam; 3.30.160.60:FF:000674; zinc finger transcription factor Trps1 isoform X2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR InterPro; IPR028440; TRPS1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR47034; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR PANTHER; PTHR47034:SF1; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF27058; Znf_C2H2_Trps1_1st; 1.
DR Pfam; PF27065; Znf_C2H2_Trps1_2nd; 1.
DR Pfam; PF27047; Znf_C2H2_Trps1_3rd; 1.
DR Pfam; PF27082; Znf_C2H2_Trps1_4th; 1.
DR Pfam; PF27088; Znf_C2H2_Trps1_5th; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000515131};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 698..726
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 896..954
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 1..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..89
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1065
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 141661 MW; 5D23D83168C54DBA CRC64;
MKSMLDMVRK KNPPLRNVVS EGEGQTLEPI GTESKVSGKN KEFSADQMSE NTDQSDAAEL
NNKEEHRLHG QDSSSSSKKG PKSSSLSEKA GFNYESPSKG GNLPSHPHDE VTDRNMLAFS
SPAVGGVCEP LKSPQRAEAD DPQDTACTPA GDSLETKEDH KMSPKATEET GQAQSSQANC
QGSSPVSVAS KNPQVPSDGG VRLNKSKTDL LVNDNPDPAP LSPELQDFKC NICGYGYYGN
DPTDLIKHFR KYHLGLHNRT RQDAELDSKI LALHNMVQFS HSKDFQKVNR SVLSGVLQDI
NSSRPVLLNG TYDVQVTSGG TFIGIGRKTP DCQGNTKYFR CKFCNFTYMG NSSTELEQHF
LQTHPNKIKA SLPSSEGAKP SEKNSNKSIP ALRSGDSGDL GKWQDKITVK AGDDTPVGYS
VPIKPLDSSR QNGTEATSYY WCKFCSFSCE SSSSLKLLEH YGKQHGGAQS GCLNPELNDK
LSRGSVINQN DLAKSAEGEP MTKADKGSSG AKKKDFSSKG AEDNMVTSYN CQFCDFRYSK
SHGPDVIIVG PLLRHYQQLH NIHKCTIKHC PFCPRGLCSP EKHLGEITYP FACRKSSCSH
CALLLLHLSP GAAGSSRVKH QCHQCSFSTP DVDVLLFHYE SVHESQASDV KQEANHLQGS
DGQPAVKESK EHSCTKCDFI TQVEEEISRH YRRAHSCYKC RQCSFTAADT QSLLEHFNTV
HCQEQDITTA NGEEDGHAVS AIKEEPKIDL KVYSLLNPDS KMGEPVSESV VKREKVEDKD
GLKEKVWTES SSDDLRNMTW RGADILRGSP SYTQASLGLL TPVSGTQEQT KTLRDSPNVE
AAHLARPIYG LAVETKGFLQ GVPAGGEKSG PLTQQYPASG ENKSKDESQS LLRRRRGSGV
FCANCLTTKT SLWRKNANGG YVCNACGLYQ KLHSTPRPLN IIKQNNGEQI IRRRTRKRLN
PEALQAEQLN KHQRGGSEEQ VNGSPLERRS EDHLTEGHQR EIPLPSLSKY EAQGSLTKSH
SAQQPVLVSQ TLDIHKRMQP LHIQIKSPQE STGDPGNSSS VSEGKGSSER GSPIEKYMRP
AKHPNYSPPG SPIEKYQYPL FGLPFVHNDF QSEADWLRFW SKYKLSVPGN PHYLSHVPGL
PNPCQNYVPY PTFNLPPHFS AVGSDNDIPL DLAIKHSRPG PTANGASKEK TKAPSSVKSE
GPLNVVKTEK VDRSTQDELS TKCVHCGIVF LDEVMYALHM SCHGDSGPFQ CSICQHLCTD
KYDFTTHIQR GLHRNNAQAE KNGKPKE
//
