ID A0A6P6HWF9_PUMCO Unreviewed; 2963 AA.
AC A0A6P6HWF9;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 08-OCT-2025, entry version 24.
DE RecName: Full=Neurobeachin {ECO:0000256|ARBA:ARBA00073055};
DE AltName: Full=Lysosomal-trafficking regulator 2 {ECO:0000256|ARBA:ARBA00080802};
GN Name=NBEA {ECO:0000313|RefSeq:XP_025779841.1};
OS Puma concolor (Mountain lion) (Felis concolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma.
OX NCBI_TaxID=9696 {ECO:0000313|Proteomes:UP000515131, ECO:0000313|RefSeq:XP_025779841.1};
RN [1] {ECO:0000313|RefSeq:XP_025779841.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025779841.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBUNIT: Interacts with RII subunit of PKA.
CC {ECO:0000256|ARBA:ARBA00065599}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat neurobeachin family.
CC {ECO:0000256|ARBA:ARBA00008498}.
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DR RefSeq; XP_025779841.1; XM_025924056.1.
DR GeneID; 112860844; -.
DR KEGG; pcoo:112860844; -.
DR CTD; 26960; -.
DR Proteomes; UP000515131; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter.
DR GO; GO:0008104; P:protein localization; IEA:TreeGrafter.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 2.130.10.10:FF:000036; Neurobeachin isoform A; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR FunFam; 2.30.29.30:FF:000059; neurobeachin isoform X1; 1.
DR FunFam; 2.60.120.200:FF:000010; neurobeachin isoform X2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000515131};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2143..2251
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2270..2580
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1486..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1837..1856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1851
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_025779841.1"
SQ SEQUENCE 2963 AA; 330118 MW; E150D951AF522213 CRC64;
SEKPGPGGSS PQPVGLCVGR GXRGGGRGRR KGGGSGMGEL EGASGSSVVL PAGMINPSVP
IRNIRMKFAV LIGLIQVGEV SNRDIVETVL NPLVGGEFDL EMNFIIQDAE SITCMTELLE
HCDVTCQAEI WSMFTAILRK SVRNLQTSTE VGLIEQVLLK MSAVDDMIAD LLVDMLGVLA
SYSITVKELK LLFSMLRGES GIWPRHAVKL LSVLNQMPQR HGPDTFFNFP GCSAAAIALP
PIAKWPYQNG FTLNTWFRMD PLNNINVDKD KPYLYCFRTS KGVGYSAHFV GNCLIVTSLK
SKGKGFQHCV KYDFQPRKWY MISIVHIYNR WRNSEIRCYV NGQLVSYGDM AWHVNTNDSY
DKCFLGSSET ADANRVFCGQ LGAVYVFSEA LNPAQIFAIH QLGPGYKSTF KFKSESDIHL
AEHHKQVLYD GKLASSIAFT YNAKATDAQL CLESSPKENA SIFVHSPHAL MLQDVKAIVT
HSIHSAIHSI GGIQVLFPLF AQLDNRQLND SQVETTVCAT LLAFLVELLK SSVAMQEQML
GGKGFLVIGY LLEKSSRVHI TRAVLEQFLS FAKYLDGLSH GAPLLKQLCD HILFNPAIWI
HTPAKVQLSL YTYLSAEFIG TATIYTTIRR VGTVLQLMHT LKYYYWVINP ADSSGITPKG
LDGPRPSQKE IISLRAFMLL FLKQLILKDR GVKEDELQSI LNYLLTMHED ENIHDVLQLL
VALMSEHPAS MIPAFDQRNG IRVIYKLLAS KSESIWVQAL KVLGYFLKHL GHKRKVEIMH
THSLFTLLGE RLMLHTNTVT VTTYNTLYEI LTEQVCTQVV HKPHPEPDST VKLXTRANMI
LKVVATLLKN STPSAELMEV RRLFLSDMIK LFSNSRENRR CLLQCSVWQD WMFSLGYINP
KNSEEQKITE MVYNIFRILL YHAIKYEWGG WRVWVDTLSI AHSKVTYEAH KEYLAKMYEE
YQRQEEENIK KGKKGNVSTI SGLSSQTTGA KGGMEIREME DLSQSQSPES ETDYPVSTDT
RDLLMSTKVS DGILGNSDRP GGGVHVEVHD LLVDIKAEKV EATEVKLDDM DLSPETLVGG
ENGALVEVES LLDNVYSAAV EKLQNNVHGS VGIIKKNEEK DNGPLITLAD EKDELPNSST
SFLFDKIPKQ EEKLLPELSS NHIIPNIQDT QVHLGVSDDL GLLAHMTGSV DLSCTSSIIE
EKEFKIHTTS DGTSSISERD LASSSRGLEY AEMTATTLET ESSASKIVPN IDAGSIISDT
ERSDDGKESG KEIRKIQTTA TTQAVQGRSI TQQDRDLRVD LGFRGMPMTE EQRRQFSPGP
RTTMFRIPEF KWSPMHQRLL TDLLFALETD VHVWRSHSTK SVMDFVNSNE NIIFVHNTIH
LISQMVDNII IACGGILPLL SAATSPTGSK TELENIEVTQ GMSAETAVTF LSRLMAMVDV
LVFASSLNFS EIEAEKNMSS GGLMRQCLRL VCCVAVRNCL ECRQRQRDRG SKSSHGSSKP
QEAPQSVTAT AASKTPLESV PGNLSPIKDP DRLLQDVDIN RLRAVVFRDV DDSKQAQFLA
LAVVYFISVL MVSKYRDILE PQRETTRTGS QPGRNIRQEI NSPTSTVVVI PSIPHPSLNH
GFLAKLIPEQ SFAHSFYKET PATFPDTIKE KETPTPGEDI QLESSIPHTD SGIGEEQVAS
ILNGAELEPG TGPDAMSELL STLSSEVKKS QESLTENPSE LLKPAPSISS ISQTKGINVK
EILKSLVAAP VEIAECGPEP IPYPDPALKR EAQAILPMQF HSFDRSVVVP VKKPPPGSLA
VTTVGATAAG SGLTTGSTSN IFAATGATPK SMINTTGAVD SGSSSSSSSS SFVNGATSKN
LPAVQTVAPM PEDSAENMSI TAKLERALEK VAPLLREIFV DFAPFLSRTL LGSHGQELLI
EGLVCMKSST SVVELVMLLC SQEWQNSIQK NAGLAFIELI NEGRLLCHAM KDHIVRVANE
AEFILNRQRA EDVHKHAEFE SQCAQYAADR REEEKMCDHL ISAAKHRDHV TANQLKQKIL
NILTNKHGAW GAVSHSQLHD FWRLDYWEDD LRRRRRFVRN AFGSTHAEAL LKAAVEYGTE
EDVVKSKKTF RSQAIVNQNA ETELMLEGDD DAVSLLQEKE IDNLAGPVVL STPAQLIAPV
VVAKGTLSIT TTEIYFEVDE DDPAFKKIDT KVLAYTEGLH GKWMFSEIRA VFSRRYLLQN
TALEVFMANR TSVMFNFPDQ ATVKKVVYSL PRVGVGTSYG LPQARRISLA TPRQLYKSSN
MTQRWQRREI SNFEYLMFLN TIAGRTYNDL NQYPVFPWVL TNYESEELDL TLPGNFRDLS
KPIGALNPKR AVFYAERYET WEDDQSPPYH YNTHYSTATS TLSWLVRIEP FTTFFLNAND
GKFDHPDRTF SSVARSWRTS QRDTSDVKEL IPEFYYLPEM FVNSNGYNLG VREDEVVVND
VGLPPWAKKP EDFVRINRMA LESEFVSCQL HQWIDLIFGY KQRGPEAVRA LNVFHYLTYE
GSVNLDSITD PVLREIPEVY FIRDPHTFLL TKDFIKAMEA QIQNFGQTPS QLLIEPHPPR
SSAMHLCFLP QSPLMFKDQM QQDVIMVLKF PSNSPVTHVA ANTLPHLTIP AVVTVTCSRL
FAVNRWHNTV GLRGAPGYSL DQAHHLPIEM DPLIANNSGV NKRQITDLVD QSIQINAHCF
VVTADNRYIL ICGFWDKSFR VYSTETGKLT QIVFGHWDVV TCLARSESYI GGDCYIVSGS
RDATLLLWYW SGRHHIIGDN PNSSDYPAPR AVLTGHDHEV VCVSVCAELG LVISGAKEGP
CLVHTITGDL LRALEGPENC LSPRLISVSS EGHCIIYYER GRFSNFSING KLLAQMEIND
STRAILLSSD GQNLVTGGDN GVVEVWQACD FKQLYIYPGC DAGIRAMDLS HDQRTLITGM
ASGSIVAFNI DFNRWHYEHQ NRY
//
