ID A0A6P6I203_PUMCO Unreviewed; 88 AA.
AC A0A6P6I203;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Apolipoprotein C-I {ECO:0000256|ARBA:ARBA00021680};
DE AltName: Full=Apolipoprotein C1 {ECO:0000256|ARBA:ARBA00031177};
GN Name=APOC1 {ECO:0000313|RefSeq:XP_025781874.1};
OS Puma concolor (Mountain lion) (Felis concolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma.
OX NCBI_TaxID=9696 {ECO:0000313|Proteomes:UP000515131, ECO:0000313|RefSeq:XP_025781874.1};
RN [1] {ECO:0000313|RefSeq:XP_025781874.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025781874.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Inhibitor of lipoprotein binding to the low density
CC lipoprotein (LDL) receptor, LDL receptor-related protein, and very low
CC density lipoprotein (VLDL) receptor. Associates with high density
CC lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the
CC plasma and makes up about 10% of the protein of the VLDL and 2% of that
CC of HDL. Appears to interfere directly with fatty acid uptake and is
CC also the major plasma inhibitor of cholesteryl ester transfer protein
CC (CETP). Binds free fatty acids and reduces their intracellular
CC esterification. Modulates the interaction of APOE with beta-migrating
CC VLDL and inhibits binding of beta-VLDL to the LDL receptor-related
CC protein. {ECO:0000256|ARBA:ARBA00003248}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family.
CC {ECO:0000256|ARBA:ARBA00009204}.
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DR RefSeq; XP_025781874.1; XM_025926089.1.
DR AlphaFoldDB; A0A6P6I203; -.
DR GeneID; 112862870; -.
DR KEGG; pcoo:112862870; -.
DR Proteomes; UP000515131; Unplaced.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:TreeGrafter.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005504; F:fatty acid binding; IEA:TreeGrafter.
DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:TreeGrafter.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:TreeGrafter.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:TreeGrafter.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:TreeGrafter.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:TreeGrafter.
DR GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:TreeGrafter.
DR Gene3D; 4.10.260.30; Apolipoprotein C-I; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; APOLIPOPROTEIN C-I; 1.
DR PANTHER; PTHR16565:SF2; APOLIPOPROTEIN C-I; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000515131};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW VLDL {ECO:0000256|ARBA:ARBA00023313}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..88
FT /note="Apolipoprotein C-I"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028064410"
SQ SEQUENCE 88 AA; 9684 MW; 97E78C3187F3AA25 CRC64;
MSLILSLPVW VVVLSLVLEG LALAQAAPQI SSTLELILDK LKEFGKALKD KALAAIESIK
QSDIPAKTQN WFSKTFNKGK ERLKITFS
//
