ID A0A6P6KRQ0_CARAU Unreviewed; 722 AA.
AC A0A6P6KRQ0;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE SubName: Full=Interleukin-6 receptor subunit beta-like isoform X2 {ECO:0000313|RefSeq:XP_026074979.1};
GN Name=LOC113053994 {ECO:0000313|RefSeq:XP_026074979.1};
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026074979.1};
RN [1] {ECO:0000313|RefSeq:XP_026074979.1}
RP IDENTIFICATION.
RC STRAIN=Wakin {ECO:0000313|RefSeq:XP_026074979.1};
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_026074979.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_026074979.1; XM_026219194.1.
DR AlphaFoldDB; A0A6P6KRQ0; -.
DR GeneID; 113053994; -.
DR Proteomes; UP000515129; Chromosome 35.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-ARBA.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR052672; Type1_Cytokine_Rcpt_Type2.
DR PANTHER; PTHR48423; INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR48423:SF1; INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..722
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028469409"
FT TRANSMEM 624..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..325
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 330..423
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 522..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 722 AA; 82155 MW; A9F6617038BD59F0 CRC64;
MDTSHHLLLL LMLLHYEAGF SHSCLKILPD SNSRIALEVG KNFTATCHLL EGSAHTSDNI
EWTMRDIPIP KQFYHKINET AVSVTVNISS DMRGWLRCKA KESQPDCYIY GISLHPGYPP
LKPTNLSCVA VQEGEDMSPN LNCSWDSGSR NPLFDTTYTV YAYITILNKT YTADCKQHHL
DRYCVVNLER FPHHVRLKVW VEVKNVLGSE RSEQLQNYSE YFVKTNPPLN IQVLTEDNFS
TSLMVTWEPP IQEYVLTLSY AIRYRKASSD VWVEVPENLT KVYTFRLQSL EPYTQYVVQI
RCIGESPSRY WSNWSAGVTG HTSEDKPASA PDLWRIIRST SNNRNVTLVW KAPVKANGKI
LGYYLNICHD YVMIESHNIT ADNRLMYLMK LPPGKNASIE LTAYNSVGAS PKATLFIPRS
GEDLPGVKNM SWSVRDEKLQ VQWTAVTSLP VGLRLSEYLL EWVTVPQLQA GWQRVSSKVH
NTTLNGDLKK FQRYNISVYP IYKYQQAGRP VTRPAYVQQG IPEKGPNVTQ TKSKKNSAEL
TWNEIPLERQ RGFITNYTIF YAIGSTKQWK SVTVNPNVQS YLLMDLASET DYVVNIMAST
VAGSVKGIDY NFKTLKYGDG EVEVIVVVVC LSFLFLTVFI IMFCLRKREV IKKLLWPQVP
DPSDSSIAHW SPDFPIKEED LVLIEADSSR QNLRPDATTS NVAITLRSEK NVIRHAAAQI
NT
//
