ID A0A6P6LA37_CARAU Unreviewed; 596 AA.
AC A0A6P6LA37;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE SubName: Full=Suppressor of cytokine signaling 5-like isoform X2 {ECO:0000313|RefSeq:XP_026080241.1};
GN Name=LOC113057226 {ECO:0000313|RefSeq:XP_026080241.1};
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026080241.1};
RN [1] {ECO:0000313|RefSeq:XP_026080241.1}
RP IDENTIFICATION.
RC STRAIN=Wakin {ECO:0000313|RefSeq:XP_026080241.1};
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_026080241.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_026080241.1; XM_026224456.1.
DR AlphaFoldDB; A0A6P6LA37; -.
DR GeneID; 113057226; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515129; Chromosome 38.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 440..535
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 530..579
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 127..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..204
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 66746 MW; B20F54B1EAE11167 CRC64;
MWDSSESNSF KSLQTKDGCE VIFTKKKGCC LHSMEKVSKM WGNLRSRCQA LFHNDGSESH
LCSQDLDCVH RVVDLGRGTH AEPYETRSFT PSRTVSPLPL VPGGRRAHNC VADIPQIVEI
SIDKESEDAR RGPLVRRDSY SRHAPWGGKK KHSCSTKTQS SLEADRRTGR SRGSTARRER
RYGVSSIQEI NDSVGAGSSG RSLSTRSLRQ RLRETVGLCL PLPTQHRSQS AKGQVSSKRK
IHLTELMLET CPFPPGSDLA NKWHLIKQHT APVSPHSSTA LLDAFDSAHP SPEDEEERLR
ERRRLSIEEG VDPPPNAQIH TLEATSQNSS LYKLGPKMAP GVAEGLGEGR SLGKVSSISG
VLSGIAPQVA ASMAVPSHTV DCDSEEDSTT LCLQTRRPKQ RHASGDTHCS RQPGPWKVHT
QIDYIHCLVP DLQAITALPC YWGVMDRYQA EALLDGRPEG TFLLRDSAQE DYLFSVSFRR
YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSACMFFEPL LTAPLHRTFP
FSLQHLARAA ICRHTTYDGI GALPLPPTMQ DFLKEYHYKQ KVRVRWLERE PPLKVK
//
