ID A0A6P6LMU5_CARAU Unreviewed; 421 AA.
AC A0A6P6LMU5;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=LOW QUALITY PROTEIN: suppressor of cytokine signaling 4-like {ECO:0000313|RefSeq:XP_026084997.1};
GN Name=LOC113060347 {ECO:0000313|RefSeq:XP_026084997.1};
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026084997.1};
RN [1] {ECO:0000313|RefSeq:XP_026084997.1}
RP IDENTIFICATION.
RC STRAIN=Wakin {ECO:0000313|RefSeq:XP_026084997.1};
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_026084997.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_026084997.1; XM_026229212.1.
DR GeneID; 113060347; -.
DR KEGG; caua:113060347; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515129; Chromosome 42.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 275..370
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 365..414
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 69..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 48191 MW; 0F1635EA30829D54 CRC64;
MHFLPSVHAE LSLHELHAWK NXLLLCEDIS FSYTLFQKGP EAMSERKPKN SDTRPKNLRS
WSADSYIRSI KKRSHGSRHE TAPRGEEGEG IDDQTVRSAS SPRRRRERKC SCTVPGEPDL
DSPCRKALSR RSLRQKFQDA VGQCLPLRNH HHHHHQSGSS RPFSILLWSK RKIHVSELME
DKCPFSPKSE LAQCWHLIKK HGTHTKPSLS IETEPKCPLL SSSPPTLISW EEISSSGASS
LDDWDPSLAH GDAQCCAHTD YILVPDLLQI NNSPCYWGVL DRFEAEQLLE GQPEGTFLLR
DSAQDEYLFS VSFRRYSRSL HARIEQNGKR FSFDGRDPCM YRDPSVTGLL RHYSDPATCL
FFEPLLSRPL SRNFPFSLQH MCRAVICSCT TYQGIDTLPL PYSLRLFLRQ YHYRCNGACA
V
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