ID A0A6P6M8K9_CARAU Unreviewed; 347 AA.
AC A0A6P6M8K9;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE SubName: Full=Connective tissue growth factor-like {ECO:0000313|RefSeq:XP_026092597.1};
GN Name=LOC113065514 {ECO:0000313|RefSeq:XP_026092597.1};
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026092597.1};
RN [1] {ECO:0000313|RefSeq:XP_026092597.1}
RP IDENTIFICATION.
RC STRAIN=Wakin {ECO:0000313|RefSeq:XP_026092597.1};
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_026092597.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_026092597.1; XM_026236812.1.
DR AlphaFoldDB; A0A6P6M8K9; -.
DR Ensembl; ENSCART00000152693; ENSCARP00000135931; ENSCARG00000070348.
DR GeneID; 113065514; -.
DR KEGG; caua:113065514; -.
DR OrthoDB; 365605at2759; -.
DR Proteomes; UP000515129; Chromosome 48.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0008201; F:heparin binding; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF22; CCN FAMILY MEMBER 5; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..347
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027759327"
FT DOMAIN 22..98
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 103..167
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 259..333
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 347 AA; 38296 MW; 96BE0B2CD73C4B67 CRC64;
MMDKLQRDRN SLMAWALLFY LGSQVCCQQC GSPCQCQSSL PDCQEGVPLI LDGCQCCQVC
ARQQGEACSE LFPCDIQRGL QCDYSASFPG DPGECVSQKE LGCEHNGVSY QEGQVFQPSC
ALQCRCSGGG VTCVPRCSED VLLPTPDCPH PRRVQQPGKC CKVWVCENMD NTVLQDAHIA
SGSDQTLPAD SAYQTRPGSN CIDQSSEWSA CSHTCGPGIS TRVSNQNLAC RLEMQMRLCM
IRPCQPVLQR NPQWPRRKCQ PTYRSATPVR LFHQGCYSTQ FYRPRYCGTC KDNRCCTPYH
TGTALVTFRC PGGRLLNHAV MTISSCICHY NCPYSSGGAY RGSPFLG
//
