ID A0A6P6N719_CARAU Unreviewed; 471 AA.
AC A0A6P6N719;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 18-JUN-2025, entry version 24.
DE SubName: Full=Regulator of G-protein signaling 6-like isoform X2 {ECO:0000313|RefSeq:XP_026089016.1, ECO:0000313|RefSeq:XP_026104842.1};
GN Name=LOC113076406 {ECO:0000313|RefSeq:XP_026104842.1};
GN Synonyms=LOC113063069 {ECO:0000313|RefSeq:XP_026089016.1};
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026104842.1};
RN [1] {ECO:0000313|RefSeq:XP_026089016.1, ECO:0000313|RefSeq:XP_026104842.1}
RP IDENTIFICATION.
RC STRAIN=Wakin {ECO:0000313|RefSeq:XP_026089016.1,
RC ECO:0000313|RefSeq:XP_026104842.1};
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_026089016.1,
RC ECO:0000313|RefSeq:XP_026104842.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_026089016.1; XM_026233231.1.
DR RefSeq; XP_026104842.1; XM_026249057.1.
DR Ensembl; ENSCART00000123557; ENSCARP00000110458; ENSCARG00000055835.
DR GeneID; 113076406; -.
DR Proteomes; UP000515129; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08737; RGS_RGS6; 1.
DR FunFam; 1.10.10.10:FF:000162; Regulator of G-protein signaling 6; 1.
DR FunFam; 1.10.1240.60:FF:000001; Regulator of G-protein signaling 6; 1.
DR FunFam; 1.10.167.10:FF:000002; Regulator of G-protein signaling 6 isoform 9; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR037956; RGS6_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 39..114
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 335..450
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 471 AA; 54413 MW; 6A6AC92934CA18F3 CRC64;
MAQASQDLGA VGVADPDEDS PNMIAYRKIE DIITRLQDET EGVPVRTVKS FLSKIPSVVT
GSDIVQWMMK NLIIDDPAEA IHIGSLIAAQ GYIFPISDHV LTLKDDGTLY RFQAPYFWPS
NCWEPENTDY AIYLCKRTMQ NKTRLELADY EAENLARLQR AFARKWEFIF MQAEAQVKID
RKKDKTERKI LDSQERAFWD VHRPVPGCVN TTEMDIRKCR RLKNPQRVKK SVYGVVDDTQ
TQSPVHIPSL QSNKGTREDV EKEILFLNTQ LDRHCMKMSK VADTLMSYTE QYLDYDPFLT
IPEPANPWTS DDVTFWELEA SKEPSQQRVK KWAFSLDEAL KDPVGREQFL KFLESEFSSE
NLLFWLAVQD LKCRPLQEVA ARAQEIWQEF LAEGAPSAIN LDSHSYERTS QNLKDPGRYS
FEDAQDHIYK LMKSDSYPRF LRSNAYQDLL LARKKGKSLT SKRLTGLMQS S
//
