ID   A0A6P6QH07_CARAU        Unreviewed;       529 AA.
AC   A0A6P6QH07;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   28-JAN-2026, entry version 24.
DE   SubName: Full=Suppressor of cytokine signaling 5-like {ECO:0000313|RefSeq:XP_026132706.1, ECO:0000313|RefSeq:XP_026132707.1};
GN   Name=LOC113111821 {ECO:0000313|RefSeq:XP_026132706.1,
GN   ECO:0000313|RefSeq:XP_026132707.1, ECO:0000313|RefSeq:XP_026132708.1};
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000313|Proteomes:UP000515129, ECO:0000313|RefSeq:XP_026132708.1};
RN   [1] {ECO:0000313|RefSeq:XP_026132706.1, ECO:0000313|RefSeq:XP_026132707.1}
RP   IDENTIFICATION.
RC   STRAIN=Wakin {ECO:0000313|RefSeq:XP_026132706.1,
RC   ECO:0000313|RefSeq:XP_026132707.1};
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_026132706.1,
RC   ECO:0000313|RefSeq:XP_026132707.1};
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_026132706.1; XM_026276921.1.
DR   RefSeq; XP_026132707.1; XM_026276922.1.
DR   RefSeq; XP_026132708.1; XM_026276923.1.
DR   AlphaFoldDB; A0A6P6QH07; -.
DR   GeneID; 113111821; -.
DR   KEGG; caua:113111821; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000515129; Chromosome 12.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515129};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          374..469
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          464..513
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          102..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   529 AA;  58714 MW;  0D0414BFA11EDA32 CRC64;
     MEKVGKVWSN LKRGCQSLLH TDGGSRIETP PPQLQPQRET VCKSVDKAQG DITLEAASPS
     SSVEALPLVA WRTGGSVTRQ GHNCVVDVPQ ILEITVEQDT EDARVPMGAR RDSYTRHAPW
     SGKKRHSCST KAQSSLETTD RRSGRSRRRH GTGSSHEELE SGGTRSLRQQ IHDTVGLCLP
     LRSSSRNSHL PPPKRKIQIT ELMLETCPFA PGSDLARKWH LIKQHTAPVP VSPVDSSSGA
     CGAICASPED EEERLRERRR LSIEEGVDPP PDAQIHTVEA ATAPLVSLYK LGPKLAPGIG
     EALGDSRGAT AASCDSEDDD TTTLCLQARR PKQRHASAEG HLSSKQQGPW KVHTQIDYIH
     CLVPDLLQIT ALSCYWGVMD RYEAEALLDG RPEGTFLLRD SAQEDYLFSV SFRRYGRSLH
     ARIEQWNHNF SFDAHDPCVF HAATVTALLE HYKDPSACMF FEPLLTVPLH RTFPFGLQSL
     ARSAICNGIT YDGIGALPLP PALQDHLREY HYKQRVRVRW LEKEPVKAK
//