ID A0A6P6WX27_COFAR Unreviewed; 906 AA.
AC A0A6P6WX27;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE SubName: Full=Late blight resistance protein homolog R1A-3 {ECO:0000313|RefSeq:XP_027119973.1};
GN Name=LOC113736949 {ECO:0000313|RefSeq:XP_027119973.1};
OS Coffea arabica (Arabian coffee).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Gardenieae complex;
OC Bertiereae - Coffeeae clade; Coffeeae; Coffea.
OX NCBI_TaxID=13443 {ECO:0000313|Proteomes:UP001652660, ECO:0000313|RefSeq:XP_027119973.1};
RN [1] {ECO:0000313|Proteomes:UP001652660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=40002058; DOI=10.3390/foods14040614;
RG RefSeq;
RA Tenea G.N., Cifuentes V., Reyes P., Cevallos-Vallejos M.;
RT "Unveiling the Microbial Signatures of Arabica Coffee Cherries: Insights
RT into Ripeness Specific Diversity, Functional Traits, and Implications for
RT Quality and Safety.";
RL Foods 14:614-614(2025).
RN [2] {ECO:0000313|RefSeq:XP_027119973.1}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_027119973.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_027119973.1; XM_027264172.2.
DR AlphaFoldDB; A0A6P6WX27; -.
DR GeneID; 113736949; -.
DR OrthoDB; 646178at2759; -.
DR Proteomes; UP001652660; Chromosome 3e.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:TreeGrafter.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR055414; LRR_R13L4/SHOC2-like.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1193; DISEASE RESISTANCE PROTEIN RPP13-RELATED; 1.
DR Pfam; PF23598; LRR_14; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP001652660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 8..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 202..358
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 440..510
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 558..843
FT /note="Disease resistance R13L4/SHOC-2-like LRR"
FT /evidence="ECO:0000259|Pfam:PF23598"
FT COILED 258..285
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 906 AA; 103206 MW; 3F2D9A632FDEA131 CRC64;
MEKAVEVAVG FVLQNLVQLI NENRALIGGN HEKISDLQDG LRLLKTFMAD YTEKHYNSRT
LMELADDIRR RVFEVEDLLE TYIVEETLYK NKNTLRQVVS AKSHLENLRK IGETVEKLSA
KVKQTYKENK DFGVPALERE EMARHNSIDE HNQIGDNEGA DRIIGFMDAT DEVLKLLGGQ
KLVLGKSEAE EQTPSEAEQH GESKQLEVVA IHGMLGLGKT TLAKKVLNDP RIEYHFFTRI
FVPVSNVYNK QEVLFSILSA FTKNIKDQNL SMKELEDKVK ETLKKKYLIV IDDVWATEAW
DDLKKVFPDN KGSRVLITTR LEPVANSVTT KTEPYKLRFM NEDEAEELLR TKVFKDNKCP
KELLSLEQKI LAKCKGLPLA IVVTAGILRN HPRDPKWWDD VLHGVAELVG DGQKIIDDVI
RRSYDNLNPI LKSCFLYLGV FPEDLEIQAS KLLQLWIAEG FIPKSEKASM EKISEACLRE
LVGRNLVMVE QRTLSGQIKT CRIHDTLRDF CKKIAKEECL FQETHVGTSS SSSARRVACK
NSHLSQYVCK KQPAENARSF LSFGQDEIKL DPNLSPDDVF KRFKLMRVLD ILSVKLPTVR
LPRKLSDLVL LKFIAINCEV EILPKTMSRL LNLQTLIVHT GSPTLDIQAD IWAMTKLRHL
ITNSSTSLPR CQEQSTTSEN LQTLSIVSPE SLTDEVLKRA TNLKKLGISG NLGTLMKANG
ESNLFDHLCE LNSLERLKLC GDDVNSKLLA LPQPHKFPKR LTKLSLQNTS LGWDQMSILG
KLRYLEVLKL KDNAFTGEDW QTEEGGFRSL KVLFIGATDL KCWEAQANDF PELRRLILRQ
CKQLLRIPPD FVDMKKLEAI HLEHTTGSAI SSARRIRQLQ TDMLQRQNLN DKKNTPIRIS
VYPPEY
//
