ID A0A6P7GHS1_DIAVI Unreviewed; 307 AA.
AC A0A6P7GHS1;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Forkhead box protein D3-like {ECO:0000313|RefSeq:XP_028145422.1};
GN Name=LOC114338993 {ECO:0000313|RefSeq:XP_028145422.1};
OS Diabrotica virgifera virgifera (western corn rootworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Chrysomeloidea; Chrysomelidae; Galerucinae; Diabroticina; Diabroticites;
OC Diabrotica.
OX NCBI_TaxID=50390 {ECO:0000313|RefSeq:XP_028145422.1};
RN [1] {ECO:0000313|RefSeq:XP_028145422.1}
RP IDENTIFICATION.
RC TISSUE=Whole insect {ECO:0000313|RefSeq:XP_028145422.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_028145422.1; XM_028289621.1.
DR AlphaFoldDB; A0A6P7GHS1; -.
DR InParanoid; A0A6P7GHS1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR CDD; cd20048; FH_FOXD4-like; 1.
DR FunFam; 1.10.10.10:FF:000016; Forkhead box protein I1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050211; FOX_domain-containing.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF402; FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 55..149
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 55..149
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 15..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 34702 MW; 6D642E894FDD7A1A CRC64;
MLTMEENCRH LTTSDIDPRF SVTDSPLDLR GSSAEQPEVK SEKDKSKKTN HQLIKPPYSY
IALITMAILQ SPHKKLTLSG ICEFIMSRFH YYREKFPAWQ NSIRHNLSLN DCFIKIPREP
GNPGKGNYWT LDPLAEDMFD NGSFLRRRKR YKRPSPNLML RDHHASAMVA SFLSSQENYH
HSIFSHASMH NPYPYIPGIA ANIPPNLPLL SPMDLSRLSL SHLGLLPQPT ICKPVPVQPP
SVTTVSDNED YGATDIKKSK HGFSIDSIMG NESNRGKNDM SPDLSLTRIH NQGSAFSPLS
SSDDWTR
//
