ID A0A6P7I148_9TELE Unreviewed; 2757 AA.
AC A0A6P7I148;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 08-OCT-2025, entry version 23.
DE RecName: Full=Neurobeachin-like protein 2 {ECO:0000256|ARBA:ARBA00068540};
GN Name=nbeal1 {ECO:0000313|RefSeq:XP_028256537.1};
OS Parambassis ranga (Indian glassy fish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Ambassidae; Parambassis.
OX NCBI_TaxID=210632 {ECO:0000313|Proteomes:UP000515145, ECO:0000313|RefSeq:XP_028256537.1};
RN [1] {ECO:0000313|RefSeq:XP_028256537.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the WD repeat neurobeachin family.
CC {ECO:0000256|ARBA:ARBA00008498}.
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DR RefSeq; XP_028256537.1; XM_028400736.1.
DR FunCoup; A0A6P7I148; 520.
DR GeneID; 114432616; -.
DR CTD; 65065; -.
DR InParanoid; A0A6P7I148; -.
DR OrthoDB; 26681at2759; -.
DR Proteomes; UP000515145; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter.
DR GO; GO:0030099; P:myeloid cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0008104; P:protein localization; IEA:TreeGrafter.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR FunFam; 2.130.10.10:FF:001375; Neurobeachin-like protein 2; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000515145};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1946..2043
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2054..2346
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2550..2591
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 761..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..777
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2757 AA; 310989 MW; 45D63F306081A1B4 CRC64;
MASNERLYEV WMLYCTKRDP DYLKLWLEIF ISSYERCLDV DFEKPSSRPE EVPPVLTLLP
DNILQVLRHQ LLQCVQKASD GLEPEQQNLA LLLLKFLIII CRNLSNVEEI GSCSYINNII
TMTTLYIQQL KSKTKEKEMA DQSQAEEFVR HALAFCESLY DPYRNWRHRT CGEQLGTVER
SRQKYKAAQL TVEFVPFFYQ CFQESEHLKE SLKCCLLHLF GAIVAGDQRN ALLAISPATM
EVLMRVLADC SMGSCSSDEG EDWDSEAPDR KALLTLGCLR EVVQRLLASS SDQRQVEIAS
VLENYFKLLN SDPAAAVAAH QQQQQQAKGR VPTLGRHWES RFVALQVHML DTIRDMFLCS
DRPVLQAIFL NSNCFEHLTR LLQNSKLVNA RCTAADKDQK DITNNRLLTG EGDTQVFQGR
LDSLAVATIK ALTTVMLKSP AAKEVFKERI GYNHLYEVLI SLGQPSRHLL KELMNMAVEG
EHTSVGLLGI SNVEPLLLLV QWLPELDSSE HQLFTADWLR RLSCLNRQTR ATCVNAAMVM
QALAALERHE RLHRACAESL LGLVGSLGSQ SLSARELLGL LRLLRPPESG QAHPYVGPAL
RALLAVVRKQ GLESAMQYFD LSPSMAGIVV PTVQRWPGSA FSFFAWLSLD QDQLGPTSKD
KRKQLYSFFT PGGTGFEAFI SSAGVLVVAV CTKKEYVTVM LPDFCFCDSL WHSVSVAHIP
GKRPFGQSMV HIYVDGQLKL SAPLKYPTMT EPFTSCCIGS AGHRTTTPPP SQIPDPPFSS
ATTPTTRSSL GGILSPQTWG GLLGGKPESV TKLISAGTQD SEWGSPTSLQ GQLGSVMVFH
EPLQHSHVKA ICSAGPNCIS PFKAQESEFG DLSTKLLLHY SPKACQNPIC LDLSPNTLHG
RLTGKKVINW DIKDMINCVG GLPVLFPILE QLALVTPDQQ SSDPAARSDF ITPDVTTPAE
GDWVILPSNR ASEARLEKNL VATFLLVMKH FLQRHPINQE NLLHSHGVGT LGALLQKLPA
GHVDVSVLVA MQLLIEQVTY EKNQALLQQL HTHLLFNFNI WNKGDFPLRI GHIQYMSTVI
KDNRKQFRKK NGVQFLLDTM RLYYGKSANK ESDLSEDDIR TIRASLCGLI KYYISKGMSQ
EEMHSLLGYI AAIGDEDQLC GLLELLFSLL QSSPARDQLF LLLFEPGAAD SSYALLLNNK
YSDRLRELVF KLFERMLRCD RVYEKNKQRL RLREAGYSGL SLLFSELHIT PSLIRCLLNQ
VLHTDQIVNY KDLMALVQLT HRAGPSVRLI VCKRVYQLLQ SQQDAAVQIS KQQCWQDTLM
RLYLRGEGSL PLRSSDTVST CSLDLSRTSG SNRLELPLER RARAGSATRL DRLEDDRISI
GDNRSVDSLE NGDVISLLDT PSSSASTEPQ LHGKPWVVGK SGGLTLDLSH LQAYECGESG
SQTPGSMPST PSPLETSKPF PGSTSDRETT STLTEDSFLF SDNISLGESF NNAERAEEEL
CNMLLEIVLC VMWRGVEGSD DSAWLERGQV FSALTKLGTA NELLLPVDQI KLSLMERMLE
WAVSDNREAS AATLPQHTEN AVRLLHMVQD FLQAEGLVNP ALWTEKVLEE TVTLMDSLMV
WYSAGTQWFQ LSQVGLRLLL GFMAQEDPEV CAMATAKLNG ILQTKEVSSQ DEACYLLGKV
EGILRRSIQE QTEETYSFLV PLLRTLLSKV HRLLYMELHL PQLPDTNGSP SFFEDFQLYC
NSPEWRVYLD KYIIPYMKQY EIETFSQGHE TMALYWKECY EAFMVSLHKR ERERGESKIR
FQEQFVEPFS RRGRQENLRY NSMLKQQHSQ NSAIVRQWKT ARRGLVCERG PWADRQQDEM
HWRVSSAENY SRMRLKLVRN YNFDPHREAS ALRDNLGVHQ QRINPESLLL EAVKQVKVSD
LEDDILELPE DDPAASNNQV EAEEAGQKEK LVLWEDCELV TVVDVVPGRL ELTTQHIYFY
DSSQEKEEGV GHDFKWPLSQ IREVHLRRYN LRRSALEIFL IDQTNYFLNF KKEARNKVYS
RMLMLRSLSL YGTRSPQELL KASGLTQKWV NREISNFDYL MQLNTIAGRT YNNLAQYPVF
PWILADYTSE ELDLSDPRVF RDLSKPVAVL NERNAKAVRE KYESFEDPTG TIDRFHYGTH
YSNAAGVMHY LIRVEPFTSL HIQLQSGRFD CADRQFHSIP ATWQTLMDNP NDVKELIPEF
FYFPEFLENQ NGFDLGRLQI SKERVNNVIL PKWAKSPEDF IYKHRKALES EYVSAHLHEW
IDLIFGYKQR GPAAVEALNV FYYCTYEGAV DLDAITDEKE RKALEGMISN FGQTPCQLLK
EPHPVRLSQE EVEKRKAQLD TCPFSMFEHL SDLKSFFVEG ISDNIPLVKV VVPKNQSHSF
ITQGSPDTMV TVSQNCLVGT HGWLPYNKNI SNYFTFIKDP TVSNAKTQRL LSGPFAPGVE
VTAALFVVSH DGKLLFSGGH WDNSLRVTSL VKSKTVGQHI RHMDIVTCLS TDHCGIHLIS
GSRDTTCMVW QVLQQGGAPV GLCPKPIQVL YGHTDEVVSV SISTELDMAV SGSRDGTVII
HTVRRGQYMR CLRPPCDSSL PLSILHLAVS WEGHLLVHTC LEGKATLKDK NALHLYSVNG
KHLCSEPLKE QVTDMCVSGE YVVVGSEQGY LSIRDLYSLS LCTEPMAMRV PVHCVSVTKE
QSHVLVGLED GKLIIVGVGK PAEMRSGQIT RKLWGSSKRL TQISSGETVY NTQHDHN
//
