ID A0A6P7M8G5_BETSP Unreviewed; 688 AA.
AC A0A6P7M8G5;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 08-OCT-2025, entry version 22.
DE SubName: Full=Adducin 3 (Gamma) a isoform X3 {ECO:0000313|RefSeq:XP_029003288.1, ECO:0000313|RefSeq:XP_029003297.1};
GN Name=add3a {ECO:0000313|RefSeq:XP_029003288.1,
GN ECO:0000313|RefSeq:XP_029003297.1, ECO:0000313|RefSeq:XP_029003306.1,
GN ECO:0000313|RefSeq:XP_029003317.1, ECO:0000313|RefSeq:XP_029003327.1};
OS Betta splendens (Siamese fighting fish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Osphronemidae; Betta.
OX NCBI_TaxID=158456 {ECO:0000313|Proteomes:UP000515150, ECO:0000313|RefSeq:XP_029003306.1};
RN [1] {ECO:0000313|RefSeq:XP_029003288.1, ECO:0000313|RefSeq:XP_029003297.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm,
CC cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
CC {ECO:0000256|ARBA:ARBA00006274}.
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DR RefSeq; XP_029003288.1; XM_029147455.3.
DR RefSeq; XP_029003297.1; XM_029147464.3.
DR RefSeq; XP_029003306.1; XM_029147473.3.
DR RefSeq; XP_029003317.1; XM_029147484.3.
DR RefSeq; XP_029003327.1; XM_029147494.3.
DR GeneID; 114853726; -.
DR CTD; 556762; -.
DR GeneTree; ENSGT00940000155257; -.
DR Proteomes; UP000515150; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:TreeGrafter.
DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051016; P:barbed-end actin filament capping; IEA:TreeGrafter.
DR GO; GO:0061008; P:hepaticobiliary system development; IEA:Ensembl.
DR FunFam; 3.40.225.10:FF:000004; gamma-adducin isoform X1; 1.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR InterPro; IPR051017; Aldolase-II_Adducin_sf.
DR InterPro; IPR001303; Aldolase_II/adducin_N.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR PANTHER; PTHR10672; ADDUCIN; 1.
DR PANTHER; PTHR10672:SF5; GAMMA-ADDUCIN; 1.
DR Pfam; PF00596; Aldolase_II; 1.
DR SMART; SM01007; Aldolase_II; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000515150}.
FT DOMAIN 139..321
FT /note="Class II aldolase/adducin N-terminal"
FT /evidence="ECO:0000259|SMART:SM01007"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..604
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..663
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..688
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77147 MW; E9591AC1875A28DB CRC64;
MSADGRQEVV TTPPPPSGGT KERYFDRVDT SDPDYIRSRN MSPDLRQDFN VLEQKKRVTQ
ILQSPAFKEE LESLIKEQQR KGNNPTGLLA LRQIADFFMA SSVAGFNTSP LSLGMVTPIN
DMYSVEPATM VKGEKLTRCK LASLYRLVDL FSWAYFANSY ITARVSKEQD HILIIPRGLS
FAEASASNLV KVNIIGDVIE QGSTNLRIDA SGFSPHAAIY SMRPDIRCVV HVHTPATAAV
SSMKCGILPI SQEALLLGDV AYYSYQGSLD DQGERRELQK ALGPTTKVLV LRNHGVVALG
ETIEEAFHYI YNAHYACEIQ VNAISCAGGV DNLIVLDQEK YKSRVHDVAT AGDVNMCGQY
KWKIGELEFE SLMRMLDNLG YRTGHAYRHP VVRDKPRHKS DVEIPATVTA FMFEEDADGA
ATRLPFKFLQ QRQQREKTRW LNSPNSYTKV SVEGGAERYS SRTTTWMKAE ETGTPIRIED
PNQFVPLNTD PTEVLQRRNK IREQNRFDVM TSGPRSQHLA GIPVDEPRRV QIKVMPYVPT
EEEQMAPLPP NPFNELSEKE LEEYRKNVER RQLGLSDGEH ELTSDDGSTL SQSLSLTQSP
QSTPAKEENH TGLMNGKGAH EDEELSRRVS QLTTSAESVE ISVRAGEKIE EALSPESSPS
KSPNTKKKKK FRTPSFLKKN KKKEKTEA
//
