ID   A0A6P7PC99_BETSP        Unreviewed;       555 AA.
AC   A0A6P7PC99;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   28-JAN-2026, entry version 24.
DE   SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|RefSeq:XP_029026948.1, ECO:0000313|RefSeq:XP_029026949.1};
GN   Name=socs9 {ECO:0000313|RefSeq:XP_029026948.1,
GN   ECO:0000313|RefSeq:XP_029026949.1};
OS   Betta splendens (Siamese fighting fish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Osphronemidae; Betta.
OX   NCBI_TaxID=158456 {ECO:0000313|Proteomes:UP000515150, ECO:0000313|RefSeq:XP_029026949.1};
RN   [1] {ECO:0000313|RefSeq:XP_029026948.1, ECO:0000313|RefSeq:XP_029026949.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_029026948.1; XM_029171115.3.
DR   RefSeq; XP_029026949.1; XM_029171116.3.
DR   AlphaFoldDB; A0A6P7PC99; -.
DR   GeneID; 114867934; -.
DR   KEGG; bspl:114867934; -.
DR   CTD; 100003691; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000515150; Chromosome 13.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515150};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          403..498
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          493..542
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..47
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  62223 MW;  968B1962C4E71234 CRC64;
     MSLPKESEGR GKDRERGARP KVRQSRSEER RDAGGGRKGG KAKKKGLASH EPAAERPASD
     GFEYGELLSD LEARDKSTTS PLKESWRLQD LEISASLLGQ EMLMTKPGLA AGGSVSDLSA
     PGEFDGRGMS SSRTLRQKIQ DAMGQCFPIK THSAAAPPSP PQALSSTACA ASRRKIHLSE
     LMLDDCPFPA GSDLAQKWYL IKQHTAPITQ PPVLDCAVVC SPPTLGMATV VEDVDDRLRE
     RRRISIEQGV EPPPNAEIHT FEVTAQINPL YKHGPKLAHG MNELTGTDRA SVQQQQQQQQ
     QQQQQQQQQQ LLLQRQQQHQ LLLQSCLDTL DEVAASASAS VHTCDTISDP LVDPEVTVTN
     TPAATILPQT EHHKSHDGYR IHTQIDYIHC LVPDLLQITT LPCYWGVMDR YEAETLLEGK
     PEGTFLLRDS AQEDYLFSVS FRRYGRSLHA RIEQWNHNFS FDVHDPSVFH APTVTGLLEH
     YKDPNSCMFF EPLLSNPIHR TQPFSLQHIC RAVISSCTTY DGINMLPIPN ALKKHLKEYH
     YKQRVRVRRM DTWWE
//