ID A0A6P7PUR6_BETSP Unreviewed; 556 AA.
AC A0A6P7PUR6;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|RefSeq:XP_029030725.1};
GN Name=socs5b {ECO:0000313|RefSeq:XP_029030725.1};
OS Betta splendens (Siamese fighting fish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Osphronemidae; Betta.
OX NCBI_TaxID=158456 {ECO:0000313|Proteomes:UP000515150, ECO:0000313|RefSeq:XP_029030725.1};
RN [1] {ECO:0000313|RefSeq:XP_029030725.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_029030725.1; XM_029174892.3.
DR AlphaFoldDB; A0A6P7PUR6; -.
DR GeneID; 114870380; -.
DR KEGG; bspl:114870380; -.
DR CTD; 559639; -.
DR InParanoid; A0A6P7PUR6; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515150; Chromosome 15.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000515150};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 400..495
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 490..539
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 90..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 61558 MW; EC8EC58F841AD098 CRC64;
MWSNLKSKCQ TLFHNSSSGL SDSRVEADAV HCVVDLGQGG SPGEEEALGA SSPTRSLLPV
PVVKAARRHH NCVSDIPQIV EISIDKDTED VRGGSGVPLA RRDSYSRHAP WGGKKKHSCS
TKTQSSLEAD RRSGRLRGSG NRRDRRYGIS SIQELNDPVS GGRSLNTRSL RQRLSDTVGL
CLPLPARRRS RSCKNTVTSK RKIHLTELML ETCPFPPGSD LANKWHLIKQ HTAPVSPHSS
TALLDAFDPA HPSPEDEEER LRERRRLSIE EGVDPPPNAQ IHTLEASLPG SSLYKLGPKM
APGIGEASGD GRASGTSSSL GAGSSGACAQ LLGASASTQD CDSEEDSTTL CLQARRPKQR
HASGEGHMSR QQPGPWKVHT QIDYIHCLVP DLLQITALPC YWGVMDRYEA EALLDGRPEG
TFLLRDSAQE DYLFSVSFRR YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD
PSACMFFEPL LTAPLHRNFP FALQHLARAA ICRRTTYDGI GSLPLPPALQ DFLKEYHYKQ
KVRVRWLERE PPLKVK
//
