ID A0A6P7WJ64_9AMPH Unreviewed; 266 AA.
AC A0A6P7WJ64;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Gamma-secretase subunit APH-1 {ECO:0000256|RuleBase:RU369072};
DE Short=APH-1 {ECO:0000256|RuleBase:RU369072};
GN Name=LOC115457835 {ECO:0000313|RefSeq:XP_030043342.1};
OS Microcaecilia unicolor.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Gymnophiona; Siphonopidae; Microcaecilia.
OX NCBI_TaxID=1415580 {ECO:0000313|Proteomes:UP000515156, ECO:0000313|RefSeq:XP_030043342.1};
RN [1] {ECO:0000313|RefSeq:XP_030043342.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Potential subunit of the gamma-secretase complex, an
CC endoprotease complex that catalyzes the intramembrane cleavage of
CC integral proteins such as Notch receptors.
CC {ECO:0000256|RuleBase:RU369072}.
CC -!- SUBUNIT: Component of the gamma-secretase complex.
CC {ECO:0000256|RuleBase:RU369072}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
CC -!- SIMILARITY: Belongs to the APH-1 family.
CC {ECO:0000256|ARBA:ARBA00005577, ECO:0000256|RuleBase:RU369072}.
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DR RefSeq; XP_030043342.1; XM_030187482.1.
DR AlphaFoldDB; A0A6P7WJ64; -.
DR FunCoup; A0A6P7WJ64; 1310.
DR GeneID; 115457835; -.
DR KEGG; muo:115457835; -.
DR InParanoid; A0A6P7WJ64; -.
DR OrthoDB; 6507463at2759; -.
DR Proteomes; UP000515156; Chromosome 14.
DR GO; GO:0070765; C:gamma-secretase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0016485; P:protein processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR009294; Aph-1.
DR PANTHER; PTHR12889; GAMMA-SECRETASE SUBUNIT APH-1; 1.
DR Pfam; PF06105; Aph-1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369072};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976,
KW ECO:0000256|RuleBase:RU369072};
KW Reference proteome {ECO:0000313|Proteomes:UP000515156};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369072};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369072}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 216..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
SQ SEQUENCE 266 AA; 29120 MW; E38E1E2228FDD31D CRC64;
MGAAVFFGCT FVAFGPALAL FLFTVARDPL RVIILVAGSF FWLVSVLLSS LVWFISVHLS
NRDDAALQYG LLIFGAAVSV LLQEAFRFAY YKLLKKAKEG LAMISEDGRF PISIQQMAYV
SGLSFGIISG VFSVINILAD SIGPGIVGIH GDSPHYFITS AFLTMAIVFL HTFWGVIFFD
ACEKRRLWPL GLIVGSHLVT SGLTFLNPWY EGSLVPIYGI TLSMGVWAFV TAGGSLRNIQ
KCLACCKRQD SDQVMVYSTL QVPTEE
//
