ID A0A6P7Z5V0_9AMPH Unreviewed; 443 AA.
AC A0A6P7Z5V0;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_030070809.1, ECO:0000313|RefSeq:XP_030070810.1};
GN Name=SOCS4 {ECO:0000313|RefSeq:XP_030070809.1,
GN ECO:0000313|RefSeq:XP_030070810.1};
OS Microcaecilia unicolor.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Gymnophiona; Siphonopidae; Microcaecilia.
OX NCBI_TaxID=1415580 {ECO:0000313|Proteomes:UP000515156, ECO:0000313|RefSeq:XP_030070810.1};
RN [1] {ECO:0000313|RefSeq:XP_030070809.1, ECO:0000313|RefSeq:XP_030070810.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_030070809.1; XM_030214949.1.
DR RefSeq; XP_030070810.1; XM_030214950.1.
DR AlphaFoldDB; A0A6P7Z5V0; -.
DR GeneID; 115477844; -.
DR KEGG; muo:115477844; -.
DR CTD; 122809; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515156; Chromosome 9.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000515156};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 287..382
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 377..426
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 50660 MW; D9BB71F58259FE99 CRC64;
MAENKDRKSK NVDVKPKTCR SRSVDRRDGY VWSGQKFSWS HRTESYPGAE AGSATEKGAE
IGQITERMCS CSSLNFELDR SCGCRVLGRS LKQKLQDAMG QCFPIKACSN RHSSMLVSKR
KICIGELMLD NCPFPPKSDL AFKWHLIKQH TAPVNPKLEE DLLSDLESEG EEKAGQFQKC
CKEDTAGCLC FGHSHPHEKA NKHSTHKLNP KEESFTINVL NKNREESHID CANEAVTLCT
NSRKRNKPKW ELDEESFQAG TPPKYHTQVD FVHCLVPDLL RISNNPCYWG VMDRYAAEAL
LDGKPEGTFL LRDSAQDDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHAPDISG
LLEHYKDPSA CMFFEPLLSI PLSRTFPFSL QHLSRTVICN STTYDGIESL PVPPSMKLYL
KEYHYKSKVR VRRIDVPKQE DEK
//
