ID A0A6P8ESF0_CLUHA Unreviewed; 1457 AA.
AC A0A6P8ESF0;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen alpha-1(XVIII) chain-like isoform X4 {ECO:0000313|RefSeq:XP_031414975.1};
GN Name=LOC105894554 {ECO:0000313|RefSeq:XP_031414975.1};
OS Clupea harengus (Atlantic herring).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC Clupeidae; Clupea.
OX NCBI_TaxID=7950 {ECO:0000313|Proteomes:UP000515152, ECO:0000313|RefSeq:XP_031414975.1};
RN [1] {ECO:0000313|RefSeq:XP_031414975.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_031414975.1; XM_031559115.2.
DR GeneID; 105894554; -.
DR Proteomes; UP000515152; Chromosome 21.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1034; COLLAGEN ALPHA-1(XVIII) CHAIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000515152};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1457
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027792286"
FT DOMAIN 93..286
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 290..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..408
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..467
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..533
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..644
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..673
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..746
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..839
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..862
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1022
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1051
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 150367 MW; 8A620B850F2DD155 CRC64;
MADTRLWLCL SLMLALHTGP LHAWWWNAAT TPSPVNNPGT AAVAGTEMKE EKITDVGSEI
LDVASGIKQI MQTWDQDPRA GGAGRTGEQS TVDLTLQQIV EDPESSSVER SVDPDGNPAF
IFSKKSGVSR LAYGLLDSPF HRNFALLFRL MAANDTGMLF ALTDKSQMRI QLGVKLTRGK
LTGRQVAVYY SDSKGKTYGK ARFAPVAYFP LPTENHVWTR FAISFSANKI SFFHNCNREP
MVGTFSRSNA PQLVEAGAAI MVGQGGHQDG DKFEGQISQL TISGDPAAAE RQCYTSDDED
EDDASGSGSG DGIDTDTDDG ITTRPPKQKT QDVQLLPEPP VSRTASKGSL DTGREETGPK
GDSGFDTEGS GDTSEQEAPR EKGGKVVGSP GMKGDTGPPG PPGPPGPQGP LTEVMDAGDG
KVVHKVEGRQ GPPGPRGPSG QPGPAGRDGQ TGEKGDQGVE GAGGPHGFPG TPGNTGMKGQ
KGEHGVGQPG PPGLPGPPGN GETTFVDVEG SGGKMPVRRG PPGLPGPPGP PGPAGSGEDS
NGSGASGPNG KPGRPGPSGP MGKAGLPGPP GPRGEKGDCG TLGLPGSGGD TQDGFSVTSF
FDNWLPYFSS TAAPQGKLGN GGLPGSPGPM GPSGPPGLPG PPGPAGKVTI EQNGTEVTLV
EGPPGPPGSP GPKGPQGIPG LPGKAGFPGI AGQKGSEGPR GRDGFPGMDG FPGRPGDKGE
RGLRGERGEA GKDGGPPGPP GLPGPPGEIV FPNVGDHEGV VGIAGPPGQP GLAGRAGFPG
PMGPKGDRGE RGQSGVPTKG QKGEPGVILA ADGSRLYPGL TSQPGEPGPT GPQGPPGIPG
YPGQKGEFGM PGRPGRPGLN GLKGERGDSV GGHGGYPFPG LPGPPGPPGP PGPAGAVLSL
DSFSKNGERS RHHPVLKGDK GDQGAPGIPG FSGGTGGFDF NAYKNELKGE RGDTGMKGEK
GEAVGGGYYD QRYGGIAGPP GPPGPQGPRG DSVRGPQGPA GPQGQPGYGR PGNPGPPGPP
GPQGSNLPGA HRSSHTVNVP GPPGPPGPPG VPGLASGVMV LRTYDSMASI SRQQPEGTLV
YITDNTDLYI RVREGCRKVQ LGEYTPFPRE ENNVAAVNPP PVVQYPPDHT GPDSGASSSS
ERAPPQSEGQ SESLEIIPQS GYPHHPASPP RHPSNPSYPF NPAYPPQPGY PPQSGYPPQP
GYPPQPGYPP QPGYPPQPGY PKYTVTSHGT YPQQPPPADP RYSPSQPEGR YPDHRYPNGR
LPSSTHRRPS DPQPPASTHE HRAGPALHLI AMNHPQEGNM RGIRGADHEC FTQAQAIGMK
GTFRAFLSSR LQDLYSIVRR SDRERIPIVN LKDEELFSSW ESIFSESEGK IRANVTIFSF
DGRDVLTDDA WPEKMMWHGS STRGQRVTDS YCETWREANH ALTGMASSLQ DGRLLQQTQR
SCTNSYVLLC IENSSIA
//
