ID A0A6P8EVQ1_CLUHA Unreviewed; 1393 AA.
AC A0A6P8EVQ1;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen alpha-1(XVIII) chain-like isoform X6 {ECO:0000313|RefSeq:XP_031414977.1};
GN Name=LOC105894554 {ECO:0000313|RefSeq:XP_031414977.1};
OS Clupea harengus (Atlantic herring).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC Clupeidae; Clupea.
OX NCBI_TaxID=7950 {ECO:0000313|Proteomes:UP000515152, ECO:0000313|RefSeq:XP_031414977.1};
RN [1] {ECO:0000313|RefSeq:XP_031414977.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_031414977.1; XM_031559117.1.
DR GeneID; 105894554; -.
DR Proteomes; UP000515152; Chromosome 21.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023:SF1112; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000515152};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1393
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028324793"
FT DOMAIN 29..222
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 226..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..344
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..403
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..434
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..469
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..580
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..682
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..775
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..798
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..829
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..958
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..987
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 143618 MW; 728248C084D3DA3A CRC64;
MLHLLRFVLK LSVCLVLIES TSRAQAAVDL TLQQIVEDPE SSSVERSVDP DGNPAFIFSK
KSGVSRLAYG LLDSPFHRNF ALLFRLMAAN DTGMLFALTD KSQMRIQLGV KLTRGKLTGR
QVAVYYSDSK GKTYGKARFA PVAYFPLPTE NHVWTRFAIS FSANKISFFH NCNREPMVGT
FSRSNAPQLV EAGAAIMVGQ GGHQDGDKFE GQISQLTISG DPAAAERQCY TSDDEDEDDA
SGSGSGDGID TDTDDGITTR PPKQKTQDVQ LLPEPPVSRT ASKGSLDTGR EETGPKGDSG
FDTEGSGDTS EQEAPREKGG KVVGSPGMKG DTGPPGPPGP PGPQGPLTEV MDAGDGKVVH
KVEGRQGPPG PRGPSGQPGP AGRDGQTGEK GDQGVEGAGG PHGFPGTPGN TGMKGQKGEH
GVGQPGPPGL PGPPGNGETT FVDVEGSGGK MPVRRGPPGL PGPPGPPGPA GSGEDSNGSG
ASGPNGKPGR PGPSGPMGKA GLPGPPGPRG EKGDCGTLGL PGSGGDTQDG FSVTSFFDNW
LPYFSSTAAP QGKLGNGGLP GSPGPMGPSG PPGLPGPPGP AGKVTIEQNG TEVTLVEGPP
GPPGSPGPKG PQGIPGLPGK AGFPGIAGQK GSEGPRGRDG FPGMDGFPGR PGDKGERGLR
GERGEAGKDG GPPGPPGLPG PPGEIVFPNV GDHEGVVGIA GPPGQPGLAG RAGFPGPMGP
KGDRGERGQS GVPTKGQKGE PGVILAADGS RLYPGLTSQP GEPGPTGPQG PPGIPGYPGQ
KGEFGMPGRP GRPGLNGLKG ERGDSVGGHG GYPFPGLPGP PGPPGPPGPA GAVLSLDSFS
KNGERSRHHP VLKGDKGDQG APGIPGFSGG TGGFDFNAYK NELKGERGDT GMKGEKGEAV
GGGYYDQRYG GIAGPPGPPG PQGPRGDSVR GPQGPAGPQG QPGYGRPGNP GPPGPPGPQG
SNLPGAHRSS HTVNVPGPPG PPGPPGVPGL ASGVMVLRTY DSMASISRQQ PEGTLVYITD
NTDLYIRVRE GCRKVQLGEY TPFPREENNV AAVNPPPVVQ YPPDHTGPDS GASSSSERAP
PQSEGQSESL EIIPQSGYPH HPASPPRHPS NPSYPFNPAY PPQPGYPPQS GYPPQPGYPP
QPGYPPQPGY PPQPGYPKYT VTSHGTYPQQ PPPADPRYSP SQPEGRYPDH RYPNGRLPSS
THRRPSDPQP PASTHEHRAG PALHLIAMNH PQEGNMRGIR GADHECFTQA QAIGMKGTFR
AFLSSRLQDL YSIVRRSDRE RIPIVNLKDE ELFSSWESIF SESEGKIRAN VTIFSFDGRD
VLTDDAWPEK MMWHGSSTRG QRVTDSYCET WREANHALTG MASSLQDGRL LQQTQRSCTN
SYVLLCIENS SIA
//
