ID A0A6P8GE31_CLUHA Unreviewed; 2518 AA.
AC A0A6P8GE31;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE SubName: Full=Cullin-9 isoform X5 {ECO:0000313|RefSeq:XP_031435316.1};
GN Name=LOC105897402 {ECO:0000313|RefSeq:XP_031435316.1};
OS Clupea harengus (Atlantic herring).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC Clupeidae; Clupea.
OX NCBI_TaxID=7950 {ECO:0000313|Proteomes:UP000515152, ECO:0000313|RefSeq:XP_031435316.1};
RN [1] {ECO:0000313|RefSeq:XP_031435316.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR RefSeq; XP_031435316.1; XM_031579456.2.
DR GeneID; 105897402; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000515152; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd20347; BRcat_RBR_CUL9; 1.
DR CDD; cd20359; Rcat_RBR_CUL9; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 3.30.230.130; Cullin, Chain C, Domain 2; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR056405; ARM_CUL7_CUL9.
DR InterPro; IPR047561; BRcat_RBR_CUL9.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR055486; CUL7/CUL9_N.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047560; Rcat_RBR_CUL9.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22771:SF4; CULLIN 7-RELATED; 1.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF24742; ARM_CUL7_CUL9; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF23168; CUL7_CUL9_N; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000515152};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1215..1394
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1635..1887
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT DOMAIN 2148..2366
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 2319..2362
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 52..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..75
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..314
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..688
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1540..1551
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2518 AA; 281501 MW; 59A2A28F52D8D374 CRC64;
MVGERRNGNL LVQLGPRQQA YPEELIRQRR THDGQTEYLI RWTLLAVEDG TGTGGAEVAG
SVSSGSGAGG SGGSTSGESK AESILMWMST EDVYANCPTL LGKRKAPAQE EEESPSSSGG
GGGSFRPPDV TFDEVELSDM KTDVVNLVRR ARKQMAKTSE FAISLTHTIH VLSAYASIGS
LVGVFKETGA LDLLMELLCN KERQTRRSAG KMLRALASHD AGSRAYVLLS LSQQDGIEQH
MDFDNRFTLL ELFAETTSSE EHGISFEGIH LPQIPGKLLF SLVKRYLCVT SLMDKLNTAG
SESSIEPSSS SPSSVASDQT RLQREFEFTM AMANLISELV RVMGWDRNRQ LPMCLPSQTG
SGASDDASED EGCPRRMLRS IFQPRFTASA SLTAATAAAM ATASGATPPV APVSAAPTKK
KVANDFKTRV DFSTRSSYVE YVQDNLKSGM MVRMLEDYEE VSSGDEGEFR YSNDGSPPVQ
VYWNSLSRTY WVHWHMIEIL GSGTSGQSEK ETQEKASTLT ETLKLTAVSQ TFFSKPPGGL
YSLPYLCEDE REDGAQLSRA EWWEVLFFIK KLEPEQQQEV NHILRQNLDE AQMSELDEVS
LLQLCVTGEV VRKILHYLKQ TLQSSCLGDL LCSQAFAKHY LRRGGAGLQD EDPLTAAATL
LGGRRSPPSS SSSSGIAVSS SSAMGSVSKK PKKEPATEGG SEGGGGSDTE SELPTEDETK
YPEDLEEKMK AFNSPKVQGK KTALEKMGEV VDMMRKGGSG SDAGRQLAAI KVMIKLLEEE
GPQEKRTLCD SAQAIRDKVL KLLVEMIGSQ VKVDAVAALR LTRALMLKYE WRVSFATEGG
VKAILSSMQE FSTCTQVQQI ALATLKVITG ASKHDMRSVG SCVPLSESGT QMMLEIFASI
GSATPEGSKG LLSTIPNAIE LMLNTPRCSL SVCNGLLVVI MLISSHKSLA EQLVACGISP
VLKKCLSSQR SETTTLAIIA LNHISMVHKL EKKESKEELE FKDTELKMLV VSLKSMTATK
EVVQTLEQLL CDSAHLEDEK NEVTYNRDTF QDLVCLMDQH RVDRALQLSI LRILCKFLDN
YQEDLLPWHE SIEPCLSSMT AFINDRDVVQ QFIRFLFRLA SLNKDYAVVM CRLGTKDALV
KALDKHSTNL LLVTELKDLI SDCEKYASLY KKMTTSVLAG CIQMVLGHIE EHRRSHQPIN
IPFFDVFLRN LCQGDLPPYH LCTAQLKSFL RSSVELKEDK CWEKVEVSSN HHRVNKLTDK
NPKTYWESNG CTGSHFINIY MHKGVVIRQL AVLVASEDSS YMPARILVQG GDDPASINTE
LNTVNVPPSA SRIVLLENMT RFWSIVQIRI KRCQQGGIDT RVHGFEVLGP KPTFWPVFKE
QLCCRTYLFY TTKAHTWCQE ILEDKTQLLQ LFNKLNSALK HEQMFADRFL PDAEAAEALG
RTCWEALITP IVQSITISEL PVLSPLAWLL SEYLDNAESS KRYKTRAAIF NSRVRRLTHL
LVHVDTSRID TEELKPPVKS KGINRSKDLK NGKEGKNKEA VVPPSSSSAV KPKMKNTSSI
AGIALCWQGV VQRQVKKFLD STCSLPDFVE RYRAMYLRLK NAMEELFGQQ TAFVLALRQG
FSAALLQLSI LTAMHVSERF AQYIDLMIQE SCGDSGSVET IRQLQQFLEP MLFLSGLELA
NTFEHFYRHY LGDRLLGQSK VWLESAVIEQ IGSCFPNRFP QQMLTNLRES EELQQEFHLY
RLQQLDKTLQ DLDEEMMEEQ SSEPEDDSEV KVLVLSPRCW AVSPPCFLDD PNKHFPAQLC
SYLTEFTNFY SSSQSIYSLN HSKPRRLQWT WLGHAELHYD SCTLYVSTLQ MYILLQFNNQ
EDLNMETLQK DTGLTMAVIA HALQPLTGDK GILTQDPEKG VLQLNQRVLS QGSSAQSFCH
LLPKQTYLNV DEDSARTLER KRNYIYCLIV QIMKAEREMH IDNLVFRVLD TCWKKEALHS
PGGVRFSCST TDVLSCVIHV ISKGYVRRNE DSPHILEFLP EDPSTPQKGQ AQFSFSNTDL
KNSSSSTKAD ISLGDESVLA QRPEDGVLEA VLFSMGRTMS QEDVLQLMQR TVQQVAGTLS
LDLDCAQHLL VHCKWNVDLL IQRYTDDPDT LVLAAGLKIR NPQPPPSPSV QCPVCLVAQS
GGSEPAPTLC CNHYCCRSCW QEYLTARIEQ NLVMNCNCPI TDCRSQPTSQ FFYNILTDKD
TISKYENALL RGYVECCSNL TWCTNPLGCD QILCKENIGS MGTCSKCCWS SCFSCNFPEA
HYPASCSHMS QWMDDGGYYD GMTMEAQSKH LAKLISKRCP SCQAQIEKNE GCLHMTCAKC
NHGFCWRCLK PWKPTHKDYY NCSAMVSKAA RQEKKFQDYN ERCTFHNQAK DFAISLENKV
SSINEALQMK SLTFVIDACK ILAQARKVLA YSCVYSYYNQ DTEKMDVMEQ QTEALDLHTN
ALQILLEETL LQCTDLASCV RLLKPEHLNT GLELIRRIQE RLVAILQHST QVEVGEGL
//
