UniProt: A0A6P8IR85

Database: UniProt
Entry: A0A6P8IR85_ACTTE

LinkDB:  A0A6P8IR85_ACTTE 
Original site:  A0A6P8IR85_ACTTE

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
Protein domain (8)   
   InterPro (4)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (19)   

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ID   A0A6P8IR85_ACTTE        Unreviewed;       295 AA.
AC   A0A6P8IR85;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   18-JUN-2025, entry version 21.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   Name=LOC116304114 {ECO:0000313|RefSeq:XP_031569634.1,
GN   ECO:0000313|RefSeq:XP_031569636.1, ECO:0000313|RefSeq:XP_031569637.1,
GN   ECO:0000313|RefSeq:XP_031569638.1};
OS   Actinia tenebrosa (Australian red waratah sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Actinia.
OX   NCBI_TaxID=6105 {ECO:0000313|Proteomes:UP000515163, ECO:0000313|RefSeq:XP_031569636.1};
RN   [1] {ECO:0000313|RefSeq:XP_031569634.1, ECO:0000313|RefSeq:XP_031569636.1}
RP   IDENTIFICATION.
RC   TISSUE=Tentacle {ECO:0000313|RefSeq:XP_031569634.1,
RC   ECO:0000313|RefSeq:XP_031569636.1};
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the RBR family. RNF144 subfamily.
CC       {ECO:0000256|ARBA:ARBA00038342}.
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DR   RefSeq; XP_031569634.1; XM_031713774.1.
DR   RefSeq; XP_031569636.1; XM_031713776.1.
DR   RefSeq; XP_031569637.1; XM_031713777.1.
DR   RefSeq; XP_031569638.1; XM_031713778.1.
DR   FunCoup; A0A6P8IR85; 468.
DR   EnsemblMetazoa; XM_031713774.1; XP_031569634.1; LOC116304114.
DR   EnsemblMetazoa; XM_031713776.1; XP_031569636.1; LOC116304114.
DR   EnsemblMetazoa; XM_031713777.1; XP_031569637.1; LOC116304114.
DR   EnsemblMetazoa; XM_031713778.1; XP_031569638.1; LOC116304114.
DR   GeneID; 116304114; -.
DR   KEGG; aten:116304114; -.
DR   OrthoDB; 10009520at2759; -.
DR   Proteomes; UP000515163; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20349; BRcat_RBR_RNF144; 1.
DR   CDD; cd16632; mRING-HC-C4C4_RBR_RNF144; 1.
DR   FunFam; 3.30.40.10:FF:000051; RBR-type E3 ubiquitin transferase; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 1.
DR   Pfam; PF22191; IBR_1; 1.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515163};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   TRANSMEM        255..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          22..241
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
SQ   SEQUENCE   295 AA;  33257 MW;  80B3D40FC612C8A6 CRC64;
     MTGLFSTESS GENQTRQSST PKIFLCKICL SNYPVHKGLQ LKKCECIFCE ECLKHYLEHS
     ISEGNVLEIL CPDGGCSQQG DITQLEISKI LDDSKFDQYE RLRKRKEVAV DKSKTFCPIP
     GCEGVCDGIP GMAQQTYCQD CGFTFCFECK EPWHSGRTCK EYLKNSTDTT SGLRFIDILK
     EGGTNDIKEC PICQVLIQRD AGCAQMMCGN CKHMFCWHCR KSLDSDILLR HYDKGPCRNK
     LGHSRATLFL HRTQVIAGFI FFGAMILVAS PFLLIISPCF LVSKCLFRRS EPSSL
//

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