ID A0A6P8NI37_GEOSA Unreviewed; 418 AA.
AC A0A6P8NI37;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Proteasomal ubiquitin receptor ADRM1 {ECO:0000313|RefSeq:XP_033770119.1, ECO:0000313|RefSeq:XP_033770120.1};
GN Name=ADRM1 {ECO:0000313|RefSeq:XP_033770119.1,
GN ECO:0000313|RefSeq:XP_033770120.1};
OS Geotrypetes seraphini (Gaboon caecilian) (Caecilia seraphini).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Gymnophiona; Geotrypetes.
OX NCBI_TaxID=260995 {ECO:0000313|Proteomes:UP000515159, ECO:0000313|RefSeq:XP_033770119.1};
RN [1] {ECO:0000313|RefSeq:XP_033770119.1, ECO:0000313|RefSeq:XP_033770120.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. Within the complex, functions as a proteasomal ubiquitin
CC receptor. {ECO:0000256|ARBA:ARBA00053191}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). {ECO:0000256|ARBA:ARBA00065254}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_033770119.1; XM_033914228.1.
DR RefSeq; XP_033770120.1; XM_033914229.1.
DR AlphaFoldDB; A0A6P8NI37; -.
DR GeneID; 117345493; -.
DR KEGG; gsh:117345493; -.
DR CTD; 11047; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000515159; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_033770119.1,
KW ECO:0000313|RefSeq:XP_033770120.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000515159}.
FT DOMAIN 17..130
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 293..405
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 193..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..418
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 43128 MW; 9F9689B34E66F3AE CRC64;
MSSGALFPSL VSGSRGSSSK YLVEFRAGKM SLKGTTVTPD KRKGLVYIQQ TDDSLIHFCW
KDRTSGNLED DLIIFPDDCE FKRVPQCTTG RVYVLKFKAG SKRLFFWMQE PKTDKDEEYC
RKVNEYLNNP PMPGALGGSG SGGHELSALG GEGGLQSLLG NMSHNQLMQL IGPTGLGGLG
GLGALTGPGL ASLLGSGGPP ASSSSSSSRS QSTAVTPSST TSSTRVTSTP SAPAAVTSAA
ATTTTTTAAA AAAASPTTAT SSGNGASTAA SPTQPIQLSD LQNILATMNV PAVAGGGQQV
DLASVLTPEI MAPILANAAV QERLMPYLPS GESLPQTADE IQNTLTSPQF QQALSMFSAA
LASGQLGPLM SQFGLPTEAV DAANKGDVEA FASAMQTNSQ SDPKEEDKKE EEEDMSLD
//
