ID   A0A6P8SQD6_GEOSA        Unreviewed;       727 AA.
AC   A0A6P8SQD6;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   28-JAN-2026, entry version 22.
DE   RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN   Name=ZNF750 {ECO:0000313|RefSeq:XP_033817101.1};
OS   Geotrypetes seraphini (Gaboon caecilian) (Caecilia seraphini).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Gymnophiona; Geotrypetes.
OX   NCBI_TaxID=260995 {ECO:0000313|Proteomes:UP000515159, ECO:0000313|RefSeq:XP_033817101.1};
RN   [1] {ECO:0000313|RefSeq:XP_033817101.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_033817101.1; XM_033961210.1.
DR   AlphaFoldDB; A0A6P8SQD6; -.
DR   FunCoup; A0A6P8SQD6; 565.
DR   GeneID; 117368008; -.
DR   KEGG; gsh:117368008; -.
DR   CTD; 79755; -.
DR   InParanoid; A0A6P8SQD6; -.
DR   OrthoDB; 8933073at2759; -.
DR   Proteomes; UP000515159; Chromosome 10.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; IEA:TreeGrafter.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR   PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515159};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          6..57
FT                   /note="Zinc finger protein 750-like zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF15269"
FT   REGION          64..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..678
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  80885 MW;  A9FB210C4A07E758 CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVTEQD
     RVIKSPKSNS LEPKQTNQLE PLVKSSSNST TSVPLIHDSK SQHAATKDEV KENLNLQNHD
     TSKPAPQAEK LAVQKEITLS TTTTDVMHKL PVLEGVVRPS AFVPIGEHRQ IKGTENKDIP
     ELLSPSHLNN KNVPYYTKSA FHSPVHPWKT GPNFVSPDFP KISSAKGFGS IPYYMQPMMP
     EYPPHFYTEQ GLASICSTYQ FPGSPHECEN PLLSVYAAPD QRHFLTHPAQ ASGTLLSKPM
     SSLPMDHYRL MQQLHSNPTI PYAIYRAPEH TYSAYNLKPP HIAAAMNKDQ NSQLIEDANL
     LYPCSSSPSR IYPLALHKKH NECGREVLLL QTKNNMKDGQ NESENAKMSP RAGTAATGSP
     GRPSPTNFTQ TNQGSDGLFS LNKCSPSNDP SEETLTAFRP VKKSTATNDS NNLQAQHEGE
     PSSSPDVTSK NMYNQQPNHL ILSQGTLFNA MADNGLAPLN LSKKSDSIAT PSNELMCKNA
     LPLRDQSFMD TQDMPLNLSV KDSCSTISLK ISVHSPTHDS VTSTSEKKES ENFSTQVCDT
     ELHKNSRDDK NLRATQSVKM QDLQDLRIID HCDEQKQTAA VALCQLAEYS PGKIRMGNEE
     EDSQNNYSNQ AETTQSSPKN EEKLCNHKGH GQKRTQKESA KSQPASKKTK VVNSGRVFTL
     RKRARVS
//