ID A0A6P8XFX4_DROAB Unreviewed; 675 AA.
AC A0A6P8XFX4;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE SubName: Full=Xenotropic and polytropic retrovirus receptor 1 {ECO:0000313|RefSeq:XP_034111674.1};
GN Name=LOC117572721 {ECO:0000313|RefSeq:XP_034111674.1};
OS Drosophila albomicans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7291 {ECO:0000313|Proteomes:UP000515160, ECO:0000313|RefSeq:XP_034111674.1};
RN [1] {ECO:0000313|RefSeq:XP_034111674.1}
RP IDENTIFICATION.
RC STRAIN=15112-1751.03 {ECO:0000313|RefSeq:XP_034111674.1};
RC TISSUE=Whole Adult {ECO:0000313|RefSeq:XP_034111674.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR RefSeq; XP_034111674.1; XM_034255783.2.
DR AlphaFoldDB; A0A6P8XFX4; -.
DR GeneID; 117572721; -.
DR CTD; 38666; -.
DR OrthoDB; 9970435at2759; -.
DR Proteomes; UP000515160; Chromosome 3.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IEA:TreeGrafter.
DR GO; GO:0006817; P:phosphate ion transport; IEA:TreeGrafter.
DR CDD; cd14477; SPX_XPR1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; SOLUTE CARRIER FAMILY 53 MEMBER 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 3.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_034111674.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000515160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..171
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 423..627
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 639..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 78523 MW; 44CA0F43915908E4 CRC64;
MKFAEHLTAH ITPEWRKQYI NYEEMKAMLY AAIEQSPSAE LVDREMLTRY FAKFDEEFFH
YCDKELAKIN TFYSEKMAEA TRKYGSLRSE LTEAMEMGHV KKQPAWKRRT PLGKKNVPAR
KIQDLKLAFS EFYLGLILLQ NYQNLNFTGF RKILKKHDKL LSVDYGARWR TDHVEAAHFY
TNKDIDRLIQ ETEQAVTQDI EGGDRQRAMK RLRVPPLGEQ QSPWTTFKVG LFSGAFVVLF
LTVIIAAMFY GFGENWRVGL RMFRAPFLIT ECLFLWGVNV YGWRSSGVNH VLIFELDPRN
HLSEQNIMEI ASVFGVIWAC CVLCYIFCEP LGIPQYAAPL FLYTLMVAFL LNPTKTFHHE
ARYWAIRVLS RVIMAPFCFV NFADFWLADQ LNSMVPAFLD IPFLICFFGR NPTWHKAGEA
GNHCVQYVSI LHPIVAILPA YFRFAQCIRR YRDTKESFPH LVNAAKYATS FFVVIFAHKF
HTTTDTYAQS KENPWFYCWI TAALFSSCYA YIWDIKMDWG LFDAKAGENR FLREEIVYSS
TGFYYFGIIE DLILRFSWTL SMSLIQAGYI EGDVMMTILS PLEVFRRFIW NYFRLENEHL
NNVGKFRAVR DISVAPMDCS DQTTILRMMD DTDGVLNRRR GKAAGGSGGK SGNKKQKHEQ
QRLLLQGESV EDLCA
//
