ID A0A6S7DW44_9BURK Unreviewed; 645 AA.
AC A0A6S7DW44;
DT 10-FEB-2021, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:CAB3852865.1};
GN ORFNames=LMG26841_02046 {ECO:0000313|EMBL:CAB3852865.1};
OS Achromobacter dolens.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Alcaligenaceae; Achromobacter.
OX NCBI_TaxID=1287738 {ECO:0000313|EMBL:CAB3852865.1, ECO:0000313|Proteomes:UP000494272};
RN [1] {ECO:0000313|EMBL:CAB3852865.1, ECO:0000313|Proteomes:UP000494272}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 26841 {ECO:0000313|EMBL:CAB3852865.1,
RC ECO:0000313|Proteomes:UP000494272};
RA De Canck E.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CADIKW010000003; CAB3852865.1; -; Genomic_DNA.
DR RefSeq; WP_175167233.1; NZ_CADIKW010000003.1.
DR AlphaFoldDB; A0A6S7DW44; -.
DR GeneID; 94355590; -.
DR Proteomes; UP000494272; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:CAB3852865.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000494272}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 645 AA; 68762 MW; 0145CD41C41EF50C CRC64;
MIVGTAGHID HGKTTLVRAL TGVDTDRLKE EKARGISIEL GYAYTPLPNG DVLGFIDVPG
HEKLVHTMAA GASGIDFGLL VVAADDGVMP QTREHLAILS LLGVARGAVA LTKADRADPA
RLAAVRGEIA ALAADTFLRD APVFEMCAAR VGDDGVARLK QHLDDAAQAL GARDGAGLFR
LAVDRVFTLA GHGTVVTGTA HGGRARVGDD DADLRLMPAG TRVRVRGIHA QNQPSETGAA
GQRCALNLAG IDKSAITRGD WIADARCFLP SRHVDVALTL LPSADAPLRA WTPLHVHIGA
ARHVAHVVPL SADALAPGQS GWVQLVFDEL VCAMPGDRYI VRNAQATRTV GGGRVLDPNA
PDRKRRAPAR MQWLQGVADM LDGGGLQPLL AQAALGLDET ALQRLTGRAV RDLAAPEGAI
WIEPRTPQGA RTLILAAHRE ALRARVEQAL ATFHQGAPDE PGPDGSRLRR MALPAAPEAL
WQGLLDDLQQ QGRVLRNGPW LHLPGHTAAL AEAEAQLAQR LLPLLAAGAY DPPWVRDLAR
AQGEPEERVR QVLRKLLRRG EVAQVVKDLF YHRERVVELA ALAVALAGKP EGLNAAAFRD
ATGLGRKRAI QILEFFDRTG LTRRLRDTHV LRTDSAYLGA GQAVS
//
