ID A0A7D3XJK2_9BACL Unreviewed; 631 AA.
AC A0A7D3XJK2;
DT 10-FEB-2021, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:QKG84899.1};
GN ORFNames=GXN76_10750 {ECO:0000313|EMBL:QKG84899.1};
OS Kroppenstedtia pulmonis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales;
OC Thermoactinomycetaceae; Kroppenstedtia.
OX NCBI_TaxID=1380685 {ECO:0000313|EMBL:QKG84899.1, ECO:0000313|Proteomes:UP000503088};
RN [1] {ECO:0000313|EMBL:QKG84899.1, ECO:0000313|Proteomes:UP000503088}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W9323 {ECO:0000313|EMBL:QKG84899.1,
RC ECO:0000313|Proteomes:UP000503088};
RA Gulvik C.A., Batra D.G.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP048104; QKG84899.1; -; Genomic_DNA.
DR RefSeq; WP_173223041.1; NZ_CP048104.1.
DR AlphaFoldDB; A0A7D3XJK2; -.
DR KEGG; kpul:GXN76_10750; -.
DR Proteomes; UP000503088; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:QKG84899.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000503088}.
FT DOMAIN 3..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 631 AA; 70991 MW; 6843BFAF5D4F53C4 CRC64;
MTTHHFTLGT AGHIDHGKTT LTRALTGVDT DSLKEEKERN ISIEPGFAPL QLPSGLHTSI
VDVPGHERFI RQMVSGVAGI DFVLFVIAAD DGVMPQTREH LAILDLLGLK AGLIVLSKID
QADPELLPLI EEDIREIMSH TFLEGAPVLK VSSKTGEGIE SLRQELDRSL SLLSPRKSKA
PFRFPIDRVF TVDGAGTVTT GTIQSGSISA GDTMVLLPTN HKVKVRQLQV HHKTVDTAYA
GQRVALNLTH IRKEEISRGQ TLAGENTWTT TQRMDIQASL LPDLSFSLKQ RHLVTLMIGT
SEVSADLILY DRKEWTPGDK IFASLRLHQP VVAARGDRFI LRRPTPSATV GGGWVIVPDA
KPHKINPATA ELIQTWMNAS LAERILEKLS SQDLLQTPDT LARSLQEPET DIRNELEILH
QKEKVIQLNA FYASRSVMEL NEISIQDRLK DFHRSFPLRP GMSKAEWASR YFPQLPTRTG
KLLLDYWEQR GLLRQTEEMV SLFTFRPSVP APWQDAVEKV IQQIAKDALT PSDWSHYFGK
SSIPQDLEDD LYTFLIRQKH LIPLTDTLLV HFSVFQDAVY KVKSFLNQQK TMTMQDAKTL
FPLSRKYLVP LLEQMDEQGI TKRLDNKRIL A
//
