ID A0A7E6FUP9_OCTVU Unreviewed; 1262 AA.
AC A0A7E6FUP9;
DT 10-FEB-2021, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=LOC115223791 {ECO:0000313|RefSeq:XP_036371365.1,
GN ECO:0000313|RefSeq:XP_036371369.1, ECO:0000313|RefSeq:XP_036371371.1,
GN ECO:0000313|RefSeq:XP_036371374.1};
OS Octopus vulgaris (Common octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=6645 {ECO:0000313|Proteomes:UP000515154, ECO:0000313|RefSeq:XP_036371365.1};
RN [1] {ECO:0000313|RefSeq:XP_036371365.1, ECO:0000313|RefSeq:XP_036371369.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR RefSeq; XP_036371365.1; XM_036515472.1.
DR RefSeq; XP_036371369.1; XM_036515476.1.
DR RefSeq; XP_036371371.1; XM_036515478.1.
DR RefSeq; XP_036371374.1; XM_036515481.1.
DR Proteomes; UP000515154; Linkage group LG2.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20346; BRcat_RBR_ANKIB1; 1.
DR CDD; cd20361; Rcat_RBR_ANKIB1; 1.
DR CDD; cd16774; RING-HC_RBR_ANKIB1; 1.
DR FunFam; 1.25.40.20:FF:000040; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000129; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047564; Rcat_RBR_ANKIB1.
DR InterPro; IPR047563; RING-HC_RBR_ANKIB1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000515154};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 133..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 303..575
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 307..353
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 909..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 142491 MW; 1FD767389FB28118 CRC64;
MGSSSSKFRK YLQNGDEIAA LNVYNGNNEF RKSLDPNSSY GDSCNHETPV HYASRHGMRT
LLRIFLHNHH GNPNKTNSRK ETALHYVCQE RNSQYYTVRQ RRCDCLNLIL QWRGATLKDG
QTEKVDLAAQ DEKLNTALHY ASSSGLKNCV ELLVQNGSPL FIENVDQLTP CDIAEKNGHG
DIALFLESKM VFSNEGSQED HEEVVIPVSD TEEYSGLRTQ DLQEVKDQLL VETADMLSVP
LFTAEALLRN HEWSRETLLE AWMTDPFACC EKCGVTPPPS LYSDQPILPE TLNSPTTSEP
PEQDAICDIC TCTFMMSEEP VHMPCEHRFC RSCWEQYLNL KIQEGDAHHI TCPGYDCSRL
VPVDVIENVV SRPMARRYLQ FDIKAFVDSN PSMKWCPYPG CARAVHLPEI ENNTGSNSLL
STVKIPEDTS RAVDCGNGHY FCWNCLGEAH EPCCCDNWKQ WHQKIAEIKP EQFIPSHYHL
TGYLVDQQKR SIEYVPNFKQ KINGTEVETE AAANCLWLVT NSKPCPNCKS PIQKNEGCNH
MKCSKCKYDF CWVCLEQWKR HNSSTGGYFK CNRYEAVKKV EQQTQLLLSE AQARNTQMQE
LNRFVHFYTR FKNHENSYKL EVPLLNTAKE KMMKLAEAVT DHVSAKLETK FVEDAVHQLL
KARCVLKCSY VYAYYLDGPG YKKIVFECMQ TELEECTEIL SQIVNRLYLR TPRRRIIEQA
HIVQRKRHEF IAAIVKGLVP PETPPAMRKR KRKKYSIDLE DEELRKAILA SIQEVDPANP
WIKDASGRHT NVMAVLDWPD SDSDSSEADT TGTSLKSIGK CSRSGCNRLQ ALNPRTGILH
DHCSLHCLHL DHQKNNSKQQ DGLPEVFLDE QMELLRALEM SRLQYMRETG LLNIPQANSE
IDINSLDAQD NGFSTAAPNP GLNESHDTNM SEPLTTNQTD QNSSNEFSHQ LQTMLSNILN
EAVEQMQSNS SDVWVKRDLS KTENVDPATP VKSPSSNENI LSRSCNSKMS LQSEIATEEL
EQLGAYAGAQ TKPLPVSPPS TNSCFGIIKD LSVTNILATD EDKTNSFLNK DFSFGIKKNE
ISTQFQDASI SQSRSKSFDS STELNQSLDI SANNCLKKVE MTADCSDGEN EKPTGKSNFV
EKAQNTVKHF DTDCVSLLEI SQNLLHMTES LFENSEQDIA VDSSTEGPNE TNTLKSPEAS
TRDLTVNDLN TVRNGNEDQV EEGYGNQCTA SCDPAVSQEV TTRPNNTTKD HNEESNGQYF
SV
//
