ID A0A7G9W953_ALKCA Unreviewed; 635 AA.
AC A0A7G9W953;
DT 10-FEB-2021, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:QNO15215.1};
GN ORFNames=HYG86_10795 {ECO:0000313|EMBL:QNO15215.1};
OS Alkalicella caledoniensis.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales;
OC Proteinivoracaceae; Alkalicella.
OX NCBI_TaxID=2731377 {ECO:0000313|EMBL:QNO15215.1, ECO:0000313|Proteomes:UP000516160};
RN [1] {ECO:0000313|EMBL:QNO15215.1, ECO:0000313|Proteomes:UP000516160}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB2 {ECO:0000313|EMBL:QNO15215.1,
RC ECO:0000313|Proteomes:UP000516160};
RA Postec A., Quemeneur M.;
RT "Alkalicella. sp. LB2 genome.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP058559; QNO15215.1; -; Genomic_DNA.
DR RefSeq; WP_213165579.1; NZ_CP058559.1.
DR AlphaFoldDB; A0A7G9W953; -.
DR KEGG; acae:HYG86_10795; -.
DR Proteomes; UP000516160; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:QNO15215.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000516160}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 635 AA; 70979 MW; 135E3C2EC843071C CRC64;
MVNIIIGTSG HVDHGKTSLI KALTGVDTDK LKEEKERGIT IQLGFTYFQL NEETRAGIVD
VPGHEKFVRN MLAGVGGMDL VLMVVAADEG VMPQTKEHLN ILQLLNVKKG IVVVTKKDIV
DDELLELVVE DIKDAIKGTF LEKSPFIPVS SVTNEGIEEL KAEINKYISN AQIQSKSAKD
FFRLPIDRVF SLKGIGTVVT GTLKDGTISV GDTCVVYPGE RQVRVRQIQV HGEQVDTAFP
GQRSAVNLTG IEKEELSMGD LLTTFAYLKP QNKVNCILRI LDHAPELDSG TIVRFHWGTE
ETYGRAVLLD RDTLLPGESC YCQLRLEKEV VVARGDSFVI RSMSPVDTIG GGTVFNSTSK
RIPRYNMRVI KNMEINEIGE TQEIILEGIK QYGIRGITFG ELAQDLQINR REIEEVIPKL
KIEDKIVDIK DDNIVLMEKS HYNNLTSKIL AILSEYHVKY PLRIGMDKEE LRSKLGSKYS
VKLMVSILKK MQLENLVEME GLYVSLKGFQ ISLSGKELAL VNQALSLLKE SQFKPPNRED
INIPVNLLEY LVRKGDVLII GDIPFHKDVV NEGISEVIAY LKENPQGMEL SQIKDLLGTS
RKYIVPILEY YDGLGITKRS GDVRILGVKG RELSK
//
