ID A0A7H0GHW8_9BURK Unreviewed; 652 AA.
AC A0A7H0GHW8;
DT 10-FEB-2021, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:QNP47884.1};
GN ORFNames=H9K75_17375 {ECO:0000313|EMBL:QNP47884.1};
OS Diaphorobacter aerolatus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Comamonadaceae; Diaphorobacter.
OX NCBI_TaxID=1288495 {ECO:0000313|EMBL:QNP47884.1, ECO:0000313|Proteomes:UP000516028};
RN [1] {ECO:0000313|EMBL:QNP47884.1, ECO:0000313|Proteomes:UP000516028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KACC 16536 {ECO:0000313|EMBL:QNP47884.1,
RC ECO:0000313|Proteomes:UP000516028};
RA Hyun D.-W., Bae J.-W.;
RT "Genome sequence of Diaphorobacter aerolatus KACC 16536T.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP060783; QNP47884.1; -; Genomic_DNA.
DR RefSeq; WP_187723564.1; NZ_CP060783.1.
DR AlphaFoldDB; A0A7H0GHW8; -.
DR KEGG; daer:H9K75_17375; -.
DR Proteomes; UP000516028; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF9; GTP-BINDING PROTEIN 1; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:QNP47884.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000516028}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 166..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..187
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 70208 MW; 3600385138B34811 CRC64;
MIIGTAGHID HGKTSLVRAL TGVETDRLPE EKRRGISIEL GYAYLHADDG VALGFVDVPG
HEKLLHTMLA GATGIAHALL VVAADDGVMP QTREHFAVVS LLGLQRATVA ITKIDRLDAA
TRAERLAQVR AEIDTLLAAT TLAGSPVFEV SAISNEGMES LRQHLLKKAA EHDAAGSSSS
SSSASSSPHA FRMAVDRAFT LTGVGTVVTG SITSGTVSVG DELALSPGGK RVRVRGIHAL
NRQAESATQG QRSALALAGV AKDEVRRGDW ISNVGIALST TRIDVECTLW PDEERALRSG
THVHVHMGTS DVVGSIVLLE RPVLEPGETA LAQIVLRSSI AAWHGDRGVL RDASATRTLA
GIRVLDPFAP QRYRGTPERI AALKAQALPD RATRWSALLA QSAHGLDLQQ TARAEGMTGP
AAIALPGEAE RFANGNMALS PAALQSLKAH VLERLQSFHT TSPDEIGPDV KRLKRLAVPR
ADDALWSFLV ERLVADGSIM RSGHWLHRPE HAVRMNEAEQ QIAERLLPLL VNGQFDPPWV
RTLAADTQIP ETMIRQTLAS LARRGQVFQV VKDLFYPLDT IERLAEIARW CNSSDAGLEA
AAFRDATGLG RKRAIQLLEF FDRVGFTRRV KDQHLLRPGT SLFDSASSSK TD
//
