ID A0A7I8W0P9_9ANNE Unreviewed; 931 AA.
AC A0A7I8W0P9;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 13.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181};
DE AltName: Full=DRB sensitivity-inducing factor large subunit {ECO:0000256|ARBA:ARBA00029645};
DE AltName: Full=Transcription elongation factor spt5 {ECO:0000256|ARBA:ARBA00021370};
GN ORFNames=DGYR_LOCUS9971 {ECO:0000313|EMBL:CAD5122121.1};
OS Dimorphilus gyrociliatus.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Polychaeta incertae sedis; Dinophilidae; Dimorphilus.
OX NCBI_TaxID=2664684 {ECO:0000313|EMBL:CAD5122121.1, ECO:0000313|Proteomes:UP000549394};
RN [1] {ECO:0000313|EMBL:CAD5122121.1, ECO:0000313|Proteomes:UP000549394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hejnol A.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAD5122121.1}.
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DR EMBL; CAJFCJ010000016; CAD5122121.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7I8W0P9; -.
DR EnsemblMetazoa; DGYR_LOCUS9971_t1; CAD5122121.1; DGYR_LOCUS9971.
DR OrthoDB; 28901at2759; -.
DR Proteomes; UP000549394; Unassembled WGS sequence.
DR GO; GO:0032044; C:DSIF complex; IEA:TreeGrafter.
DR GO; GO:0003729; F:mRNA binding; IEA:TreeGrafter.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR FunFam; 2.30.30.30:FF:000013; Transcription elongation factor SPT5; 1.
DR FunFam; 3.30.70.940:FF:000005; Transcription elongation factor SPT5; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF23042; KOW1_SPT5; 1.
DR Pfam; PF23284; KOW2_Spt5; 1.
DR Pfam; PF23291; KOW4_SPT5; 1.
DR Pfam; PF23290; KOW5_SPT5; 1.
DR Pfam; PF23288; KOW6_SPT5; 1.
DR Pfam; PF23287; KOW7_SPT5; 1.
DR Pfam; PF23037; KOWx_SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 2.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000549394};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 146..237
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 242..269
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 384..411
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 436..463
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 558..585
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 653..680
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 726..834
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 880..907
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..34
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..811
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 103608 MW; DD842981468BAC7F CRC64;
MSDSDRSDEE MSGSDSENDK SFSEEEEEEE EEYDERPRKR SKVSNFIIDE AEVDESDEDE
EEDDRPEAGY DPKEAIRILQ EERGPSARDI DRFITPDDTL KPEDEEEINE YYKQKYAYSG
PSHSYGQGEQ MSDDISQHSI LPGVKDPNLW VVKCRMGEEK NTALHLMRKY LTYENEGQPL
LIKSVVCLEH LKGYIYIEAF KQTHVKQAID GIGNLKIGFY QQQMVPIKQM PDVLKVVQAV
GNLREGSWVR LKSGRFKGDL AQVFYCEPSQ NQICAKLIPR IDYTRKRGAL KTNEEPKKKG
RIPQKLFDPD LIKSIGGDWN TDGDYLIFEG NRYSRKGFLY KNLSVGLLIT EGVKPTMNEL
EKFEESAEKD SLDLQKLKWT EEQPFAPGDN VEVVTGELQN LQGKVVKVEG GVVEMLPKHK
ELKDRMSFPA HELRKYFHIG DHVKVLKGNF VGDTGLVVAV EDKELRIISD LSMHELLVLP
RDVQLCTDRA TGVDSAGKFE HGQMVLIEQQ QVGVIVRLER EYLHILTMHG HVKKLKETAV
QPKKSNKNAR ALDADNKEVT VGDMVKVQDG PHSGHQGQVK HIFRAFVFLH SRLVAENSGM
FVCRARHISV AGKTSSSPSN ILSGSMSPRI MSPKHPSQGA GRGRMTDGSM RNRKLIGQTV
RITQGGYKGY IGIVKDATDD TARVELHTGC NTVNVDINRL VTVNDSKSAR AVTGTFPTKT
PQGQMGGVTP SYSGGRTPMY GSQTPLYDGS RTPHYGGATP SHDGSRTPGG AWDPSASATP
KPLDDEITHS PAVSFNPYTP AAPTPPTPYA APTPSAFDSS NADWLCSDLV VRVGMDHDDA
QLRNQECIVK GATGNLATVQ VPALNNKIVS VPPHTLEPVQ PTRNNRVKVI MGDERDQTGQ
LLSSDSGEGV VKMDNGSIEM YQMNYLCKMV E
//
