ID A0A7I8W2J0_9ANNE Unreviewed; 4104 AA.
AC A0A7I8W2J0;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 14.
DE RecName: Full=Dynein axonemal heavy chain 7 {ECO:0000256|ARBA:ARBA00071816};
DE AltName: Full=Axonemal beta dynein heavy chain 7 {ECO:0000256|ARBA:ARBA00082102};
DE AltName: Full=Ciliary dynein heavy chain 7 {ECO:0000256|ARBA:ARBA00078543};
GN ORFNames=DGYR_LOCUS10198 {ECO:0000313|EMBL:CAD5122381.1};
OS Dimorphilus gyrociliatus.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Polychaeta incertae sedis; Dinophilidae; Dimorphilus.
OX NCBI_TaxID=2664684 {ECO:0000313|EMBL:CAD5122381.1, ECO:0000313|Proteomes:UP000549394};
RN [1] {ECO:0000313|EMBL:CAD5122381.1, ECO:0000313|Proteomes:UP000549394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hejnol A.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: The dynein complex consists of at least two heavy chains and a
CC number of intermediate and light chains.
CC {ECO:0000256|ARBA:ARBA00062885}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAD5122381.1}.
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DR EMBL; CAJFCJ010000017; CAD5122381.1; -; Genomic_DNA.
DR EnsemblMetazoa; DGYR_LOCUS10198_t1; CAD5122381.1; DGYR_LOCUS10198.
DR OrthoDB; 5593012at2759; -.
DR Proteomes; UP000549394; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR FunFam; 1.20.1270.280:FF:000038; AT13908p; 1.
DR FunFam; 1.20.920.30:FF:000002; Dynein axonemal heavy chain 3; 1.
DR FunFam; 1.10.8.1220:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 1.10.8.710:FF:000004; Dynein axonemal heavy chain 6; 1.
DR FunFam; 1.20.140.100:FF:000004; Dynein axonemal heavy chain 6; 1.
DR FunFam; 1.10.472.130:FF:000005; Dynein axonemal heavy chain 7; 1.
DR FunFam; 3.40.50.300:FF:002141; Dynein heavy chain; 1.
DR FunFam; 3.20.180.20:FF:000003; Dynein heavy chain 12, axonemal; 1.
DR FunFam; 1.10.287.2620:FF:000002; Dynein heavy chain 2, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000223; Dynein heavy chain 3, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000044; Dynein heavy chain 5, axonemal; 1.
DR FunFam; 3.40.50.300:FF:001328; Dynein heavy chain 6, axonemal; 1.
DR FunFam; 1.10.8.720:FF:000001; dynein heavy chain 7, axonemal; 1.
DR FunFam; 3.10.490.20:FF:000001; dynein heavy chain 7, axonemal; 1.
DR FunFam; 1.20.58.1120:FF:000005; Dynein, axonemal, heavy chain 12; 1.
DR FunFam; 1.20.920.20:FF:000006; Dynein, axonemal, heavy chain 6; 1.
DR FunFam; 3.40.50.300:FF:000362; Dynein, axonemal, heavy chain 6; 1.
DR FunFam; 1.20.1270.280:FF:000037; Dynein, axonemal, heavy chain 7; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22878; DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED; 1.
DR PANTHER; PTHR22878:SF71; DYNEIN, AXONEMAL, HEAVY CHAIN 3; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 2.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000549394}.
FT DOMAIN 1394..1533
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2036..2200
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 22..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 737..817
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2892..2957
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4104 AA; 470229 MW; 31B99863685FCBC5 CRC64;
MSSAAAHLQD YNGIGSARKK KCLPVPEKAH GSEVGLPMLS LRSNREDQNT PEFSSSNLLS
NKMKLPVLPP LPPEERDHPS DLYKMVQKHG EHPPIMRASW TQAAPFKEQK YYRTPSQSIG
NNYTPTASDL TMNDIPRIKK EMSFLQRTPR NRTSLDLTTL KSRKRKLDEK IIQRDNNGER
SRPLTPVEQL DIMKTIEEDE ARDIEEPRDQ DLERYYYYIN RGISADMLAA QDRDIMDRID
RLIPNKFLTK SAFASNLLAP LYSNLKEEVR EDYEMSLKKA IVDYILKDPT EKVRIHIKWL
PRPYPQRVIR APVPWHEQYT EAKYFHLNHL HTVNPMMSLL QKLWLEEFAD KRFVVYEELL
EADLPFHPKD FEQEVKKQCA RMHDVLRKKW VPRVCEIFKV NLNHWMHLCP DTPTGSREMA
EEFFSSIASL MSNQLRSLTI NSLNDFLKFL QIHKNGNDFG EDYVDLVYNM KQIMLIKLQV
EEPKIIFDPP FSECKEIIIR CFKEIINCND NIPRVEMELF PDSKMLLRPV RLEESLVQDI
INQALEIFQL NIVGPHNYLN SYKSYNDLLN NKAEQAVANF LKQEENDIPD FIKKIREFQN
LKDEIASLRI TVPLSMFCLN CSELNNDLCQ RANKQKEQLI SFEVSQNRRM NRDIVRRYVE
MENKVMELPE ETEELVNLQK YLTKLYGKGS MDKTVHELKK EINEAVYRLS FLLDYAFMPN
EDIKLNSQLF QWPQRILNTF ETATNRLMNR RDQVEDEVRR KRRAFEAKLE EYHKEVESYK
KKEIMSVDEM RNNVDALAKL QENLDAAKLE MEQVNTEEEL LGWEQTEYIQ LPAMVKAKEP
YEKLWNTTYL FHKKQEEWLN GPFKQLNAED IESEVQDMYR TLFKLNKSFQ DQAGPQRVAN
VYKAKIDKFK QNLPILAVIC NPGIRDRHWA QMSDIMEMDI KPGEQATLSN MLELGLSKCL
DKLEEISGAA SKEFSLEKNL KKMKVEWTDL NFEFVPYRET GIKILSAIDD IQVVLDDHII
KAQTMQGSPF IKPFEAEMKE WTEKLVSMQD IIDAWLKVQA TWLYLEPIFS SEDIMAQMPE
EGRKFGIVDA TWKDIMSEAS KDNHCLKATD QPNMLKRLQE ANVLLDEIQK GLNAYLEKKR
LYFPRFFFLS NDELLEILSE TKDPLRVQPH LKKCFEGIAK LEFTEQQEIV GMISSEKETV
ELTQKIVPAR AKGMVEKWLL QVEDVMLSSV RNVISKSIDG YKTTARNKWV LEWPGQVVIC
VSSIFWTAEV TESMKDSKGL DDYLQKSNKQ IEETVELVRG KLESGARITL GALIVIDVHA
RDVVEAMAKK NVTSANDFDW LAQLRYYWIE KHVSVRMITT ELRYGYEYLG NSGRLVITPL
TDRCYRTLMG ALKLNLGGAP EGPAGTGKTE TSKDLAKAVA KQCVVFNCSD GLDYKAMGKF
FKGLAQAGAW ACFDEFNRIE LEVLSVVAQQ IQCIQQAINS GEKKFNFEGT ELSLNPTCTM
FITMNPGYAG RQELPDNLKV LFRTVAMMVP DYALIGEISL YSMGFVDARS LSQKIVATYR
LCSEQLSSQH HYDYGMRAVK SVLTAAGNLK LKHPDTQEPE LLLKAIMDVN LPKFLAQDVP
LFEGIISDLF PGVELVKPDL GVFLEALKDN IAKRKLQQVP WFIDKIIQVY EMILVRHGLM
IVGEPMGGKT SAYQVLADAL GDLHESGLME EFKVFYRIIN PKSITMGQLY GQFDPVSHEW
SDGVLANTFR EYASNPSDDR KWILFDGPVD AVWIENMNTV LDDNKKLCLM SGEIIQMSNS
MNLIFEPADL EQASPATVSR CGMIYLEPHQ LGWKPFKESY MLHELPNTLS EDHKEMLNDM
FDWLIDPCLH FIQHNCKMLI NTSPIHLVFT LQRLLTCLLD EVRDSATEGK ELSNQQIMLW
LQGLFLFSLV WTVGGTITGE SRKKFDVFFR DLISGANSNH PKPKSSKITK SNAFPERSSV
YDFCFLKKGS GGWIDWMETI DKESTELAAN AKVSDLIIPT SETARQSFFL TTYLMHEVPV
LFVGPTGTGK SAITNSYLIK LPKDQYIPNC VNFSARTSAN QTQDIIMSKL DRRTGILIQD
HDSRDRKLRR RKGVYGPPLG KKCVVFVDDL NMPAKEKYGA QPPIELLRQW INHGHWYDRK
DTSKLFIVDN LFVAAMGPPG GGRNDITSRF TRHLQIVSID EFDDNTMSRI FTTISDWHFA
KGFDQAFNRL GKLMVQATMN VYKQTIVRFL PTPTKSHYVF NLRDFSRVIR GVLLVPSSKM
QEPDKLLRLW IHEVYRVFYD RLIDDTDRET FFNVVREVCQ DSYKQSIDKI LGHLTLSGKV
TDEHIRSLLF GDYMNPDQGP KVYDEVTDLK ELTSTIEHYL SEYNQLSKAP MSLVMFKFAI
EHVSRVSRVL LQDNGHALLA GIGGSGRQSA TKLATFMADY DLFQIEITKN YSISDWRDDI
KRLLLKAGTE GKQIVFLFSD NQIKNESFME DISMILNTGD VPNLYASDEK AEIIEKMQTV
ARNEGKKVEA TPLAMYNYFI DRVRQNLHIV LAMSPIGDAF RTRLRQFPSL INCCTIDWFQ
AWPEDALEMV ANKFLEEVDL EDNIRTESVS MCKYFHESVR QLSLKYYDTL RRMNYVTPTS
YLELILTFKK LLGQKRNEIM TLKNRYLTGL EKLEFAASQV EVMQQELTDL QPELIKTSAE
TEKLMVKIEQ DTVEVEAKKE VVAADEAVAN EAAAAAQAIK DDCESDLAEA IPALEAAISA
LNTLKPNDIT VVKSMKNPPT IVKIVMESIC VMLNMKADRK PDPGGSGKMI EDYWAASLRL
LSDLNFLNRL KTYDKDNIPP PIIKKIRDKY TSNPDFEPSV IKSASTACEG LCKWVKAMDT
YDRIARVVAP KKAKLDEAES ELAVQMDKLN AKRAQVNEVT SKLQALNDEF EAMTQKKKDL
EENIDLCTKK LERAEKLIGG LGGEKDRWTA NAKELGEKYI NITGDVLLSS AVVAYLGAFT
VDFRNEQTAI WHKICTEKEI PCSEIFSLNA TLGEPVKIRA WNIAGLPVDS FSVENGIIVA
NSRRWPLMID PQGQANKWVK NMEKSNKLNV VKLTDANYIR TLENAITFGQ PVLIENVGEE
LDPILEPVLQ KLTFRQQGVD YIKLGDNSIE YSKDFRLYMT TVLRNPHYLP EVSVKVCLLN
FMITPQGLED QLLGIVAAKE KPELEEKKNE LIVESAANKK QLKEIEDNIL EVLSSSQGNI
LEDEKAIKIL SSSKNLSEQI SAKQEIAATT EIQIDQTRNG YKPVAVHSSI LFFCISDLSN
IEPMYQYSLV WFINLYLQSI ANSEPSTDLE TRIENLNEHF SDSIYKNVCR SLFEKDKLLF
SFLLCIGILK GRGQIDDTVW RFLLTGGVAL ENPHPNPASD WLIDKSWSEI VRASDLPNLK
NFMEHVKDNI NEWKAMYDSA DPQAFKYPSP YDILSGLDRI VVLRMFRPDK IVPAVQQFIV
EHLGQSYIEP PTFDLPGSYN DSNCCAPLIF VLSPGADPMN ALLKFAEDKG YSGNKIKTIS
LGQGQGPIAS GMIDEALKNG SWVVLQNCHL ATSWMPKLEK ICEEVIIPEN THKDFRLWLT
SYPSDDFPVS ILQNGVKMTN EPPKGLRANL LRSYLNDPVS DSSYFNGGGE PHRFHKMLFG
LCFFHALVQE RRKFGPLGWN IPYEFNESDL RISLTQLRMF LTDYEELPLE ALLYLTGECN
YGGRVTDDKD RRLLNSLLGL FYCNEIIDIE SYKFSASGIY FAPKDGTYRS YVDYIRGLPL
IPHPEVFGLH ENADITKDNK ETSQLFDSIL LTLPRQTGGA GKSPGETILD LAADILSKLP
ADFDMEAVIK KYPVIYTESM NTVLRQELIR FNRLTRVVRS TLINLQKAIK GLVVMSAELE
EIFDSMLVGK VPAVWAAKSY PSLKPLGGYV SDFLARLKFF QDWIENGTPT TFWVSGFYFT
QSFFTGVSQN YARRYKIPID HLGFEFQVMS EEKEMKEKPQ DGAYIYGLFI EGARWDRDTM
VIAESHPKIL YDTIPIIWLK PGEVSKFEKR PIYDCPVYKT SARRGTLSTT GHSTNFVLWL
QLPSNKPQQH WINRGVAALC QLDD
//
