ID A0A7J6B5H1_AMEME Unreviewed; 609 AA.
AC A0A7J6B5H1;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 13.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMELA_G00048550 {ECO:0000313|EMBL:KAF4090146.1};
OS Ameiurus melas (Black bullhead) (Silurus melas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ameiurus.
OX NCBI_TaxID=219545 {ECO:0000313|EMBL:KAF4090146.1, ECO:0000313|Proteomes:UP000593565};
RN [1] {ECO:0000313|EMBL:KAF4090146.1, ECO:0000313|Proteomes:UP000593565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M_S1 {ECO:0000313|EMBL:KAF4090146.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KAF4090146.1};
RA Wen M., Zham M., Cabau C., Klopp C., Donnadieu C., Roques C., Bouchez O.,
RA Lampietro C., Jouanno E., Herpin A., Louis A., Berthelot C., Parey E.,
RA Roest-Crollius H., Braasch I., Postlethwait J., Robinson-Rechavi M.,
RA Echchiki A., Begum T., Montfort J., Schartl M., Bobe J., Guiguen Y.;
RT "A chromosome-scale genome assembly of the black bullhead catfish (Ameiurus
RT melas).";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF4090146.1}.
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DR EMBL; JAAGNN010000004; KAF4090146.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J6B5H1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000593565; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000593565};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 453..548
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 543..592
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 99..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..208
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67975 MW; 3F760F12EFCFE7A8 CRC64;
MLLTNPLSPF MRPIAAAFPL RWFPRTRPRL QAHTKEGCGE ADRAVRGPRL QSMEKVGRMW
SNLRSRCQTF FNTSDSEANV WNMDIDRVHC VVDIGTPSHG AHTGEDDQSP APSQVTLGGG
GHRGHNCVAD SPQFVEITID KESEDARRVP LVRRDSYSRH APWGGKKKHS CSTKTQSSLE
GDRRTGRSRG GSSRRERCYG SGSIQEVGDS GGGGSGRSLS TRSVRQRLKD TVGLCLPLPS
PRRLRSTKSQ VSSKRKIHIT ELMLETCPFP PGSDLANKWH LIKQHTAPVS PHSSTAMLDA
FDSTRPSPED EEERLRERRR LSIEEGVDPP PNARIHTLEA TSQRATLYKL GPKMAPCSGE
GHGEVKSSGA GTVGLSGIMA QVGASMAMPS QPVDCDSEED STTLCLQARR PKQRHASGDG
HSSRQQGPWK VHTQIDFIHC LVPDLLAITA LPCYWGVMDR YQAEALLDGR PEGTFLLRDS
AQEDYLFSVS FRRYNRSLHA RIEQWNHNFS FDAHDPCVFH SSTVTGLLEH YKDPSSCMFF
EPLLTVPLHR TFPFSLQHLA RSAICSQTTY DGIGALPLPP AMQDFLKEYH YKQKVRVRWL
EREPPFKVK
//
