ID A0A7J6BSB2_9TELE Unreviewed; 864 AA.
AC A0A7J6BSB2;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN ORFNames=G5714_022521 {ECO:0000313|EMBL:KAF4096552.1};
OS Onychostoma macrolepis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Acrossocheilinae; Onychostoma.
OX NCBI_TaxID=369639 {ECO:0000313|EMBL:KAF4096552.1, ECO:0000313|Proteomes:UP000579812};
RN [1] {ECO:0000313|EMBL:KAF4096552.1, ECO:0000313|Proteomes:UP000579812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SWU-2019 {ECO:0000313|EMBL:KAF4096552.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF4096552.1};
RA Wang D.;
RT "Chromosome-level genome assembly of a cyprinid fish Onychostoma macrolepis
RT by integration of Nanopore Sequencing, Bionano and Hi-C technology.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF4096552.1}.
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DR EMBL; JAAMOB010000023; KAF4096552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J6BSB2; -.
DR Proteomes; UP000579812; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0015485; F:cholesterol binding; IEA:TreeGrafter.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.40.160.120:FF:000005; Oxysterol-binding protein; 1.
DR FunFam; 3.30.70.3490:FF:000003; Oxysterol-binding protein; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF153; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000579812};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 474..587
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 740..852
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 308..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..681
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 94850 MW; 5DA93E6D33AA3859 CRC64;
MNSEEEFYDA ETGLESDDSC EVSFKDACVY ESKQTVNGKV PSENGVWERR TTLPAPMFSR
NDFSVWGFLK KCIGMELSKI TMPIVFNEPL SFLQRITEYM EHTYLIHKAC TLSDSIERMQ
LVAAFAISAV ASQWDRTGKP FNPLLGETFE LTRDEEGYRM ISEQVSHHPP ISAFYSESLN
QDFSFHGSIY PKLKFWGKSV EAEPKGTMTL ELSKHREAYT WTNPMCCVHN VILGKLWIEQ
YGTVEIVNHS TGDKCVLNFK PCGMFGKELH RVEGHIQDKS KKKHRVIYGK WTECVYSIEP
KVYEANKKAE KKSGGESKKH KQEQSTGGDD ADEMPDVQET VTMIPGSMLL WRVAPRPPHS
TQMYNFTNFA MTLNELEPGM IGVIAPTDCR LRPDVRAMEK GDIDTASREK ERLEEKQRAA
RRERAKDEEE WPTRWFQQGN NPYTGAADWI YKEKERNMSS GALFPSLVSG SRGSSSKYLV
EFRAGKMTLK GSTVTPDKRK GLVYIQQTDD SLIHFCWKDR STGNVEDDLI IFPDDCEFKR
VNQCTTGRVF VLKFKAGSKR LFFWLQEPKT DKDEEYCRKV NEYLNNPPIP GTLGSGGGSS
HELSALGGEG GLQSLLGNMS HNQLMQLIGP TGLGGLGGLG ALAGPGLASL LGSGVQATSS
SSSSSRSQST AATPSSTSAT TRLGSSQVPT TPITPTATVA ASPAPTPSTP TGPALSAGAT
SPTQPIQLSD LQSILATMNV PTAGQGVDLA SVLTPEVMAP ILANAEVQQR LLPYLPSGES
LPQSTEELQN TLTSPQFQQA MSMFSSALAS GQLGPLMNQF GLPTEAVEAA NKGDVEAFAK
AMEGEGKSNE GGDKKDDEED MSLD
//
