ID A0A7J8G202_MOLMO Unreviewed; 962 AA.
AC A0A7J8G202;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE SubName: Full=Polyhomeotic-like protein 1 {ECO:0000313|EMBL:KAF6453432.1};
GN ORFNames=HJG59_014136 {ECO:0000313|EMBL:KAF6453432.1};
OS Molossus molossus (Pallas' mastiff bat) (Vespertilio molossus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Molossidae;
OC Molossus.
OX NCBI_TaxID=27622 {ECO:0000313|EMBL:KAF6453432.1, ECO:0000313|Proteomes:UP000550707};
RN [1] {ECO:0000313|EMBL:KAF6453432.1, ECO:0000313|Proteomes:UP000550707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMolMol1 {ECO:0000313|EMBL:KAF6453432.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF6453432.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF6453432.1}.
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DR EMBL; JACASF010000010; KAF6453432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J8G202; -.
DR Proteomes; UP000550707; Unassembled WGS sequence.
DR GO; GO:0035102; C:PRC1 complex; IEA:TreeGrafter.
DR GO; GO:0003682; F:chromatin binding; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042393; F:histone binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:TreeGrafter.
DR CDD; cd09577; SAM_Ph1_2_3; 1.
DR FunFam; 1.10.150.50:FF:000011; Polyhomeotic-like protein 2 isoform 1; 1.
DR FunFam; 3.30.60.160:FF:000002; Polyhomeotic-like protein 2 isoform 1; 1.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR050548; PcG_chromatin_remod_factors.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF20; POLYHOMEOTIC-LIKE PROTEIN 1; 1.
DR Pfam; PF16616; PHC2_SAM_assoc; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000550707};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 749..783
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT DOMAIN 898..962
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..214
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..252
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..416
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..440
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..453
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..541
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 101528 MW; E968080CC3C26CC9 CRC64;
METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAL QALQRQPNAA QYFHQFMLQQ
QLSNAQLHSL AAVQQATIAA SRQASSPNTS TAQQQTTTTQ ASINLATTSA AQLISRSQSV
SSPSATTLTQ SVLLGNTTSP PLNQSQAQMY LRVQNLAVRN QQASAQGPQM QGSTQKAIPP
GASPVSSLSQ ASSQALAVAQ ASSGASGQSL NLSQTGGGSG TSIPGSMGPG GSGQAPGGLG
QLPSSGMGGG GSCPRKGTGV VQPLPAAQTV TVSQGSQTEA ESAAAKKAEA DGTGQQNVGM
NLTRTATPAP SQTLISSATY TQIQPHSLIQ QQQQIHLQQK QVVIQQQIAI HHQQQFQHRQ
SQLLHTATHL QLAQQQQQQQ QQQQQQQQQQ QQQQQQQQQA TTLSAPQPPQ VPPTQQVPPS
QSQQQAQTLV VQPMLQSSPL SLPPDPTPKP PIPLQSKPAV APIKPPQLGA AKMSATQQPP
PHIPVQVVGT RQPGTAQAQA LGLAQLAAAV PTSRGMPGTM QPGQAHLASS PPSSQAPGAL
QECPSTLASG MTLAPVQGTA HVVKGGATTS SPVVAQVPAA FYMQSVHLPG KPQTLGVKRK
AESEEERDDV STLASLLPAK ASAVAESPKA MEEKSSLGEK VELVTNVNTN TPSSELVSLA
PAPSAPPPTL AMVSRQMGDS KPPQAIVKPQ ILTHIIEGFV IQEGAEPFPV GCSQLLKESE
KPLQTGLLTG LNENQSCGPL GGDSPSAELD KKANLLKCEY CGKYAPADQF RGSKRFCSMT
CAKRYNVSCS HQFRLKRKKM KEFQEANYAR VRRRGPRRSS SDIARAKIQG KRHRGQEDSS
RGSDNSSYDE ALSPTSPGPL SVRAGHGERD LGNPNTAPPT PELHGINPMF LSSNPSRWSV
EEVYEFIASL QGCQEIAEEF RSQEIDGQAL LLLKEEHLMS AMNIKLGPAL KICAKINVLK
ET
//
