ID A0A7J8GB84_ROUAE Unreviewed; 495 AA.
AC A0A7J8GB84;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE SubName: Full=Ligand dependent nuclear receptor corepressor {ECO:0000313|EMBL:KAF6456732.1};
GN ORFNames=HJG63_007549 {ECO:0000313|EMBL:KAF6456732.1};
OS Rousettus aegyptiacus (Egyptian fruit bat) (Pteropus aegyptiacus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea;
OC Pteropodidae; Rousettinae; Rousettus.
OX NCBI_TaxID=9407 {ECO:0000313|EMBL:KAF6456732.1, ECO:0000313|Proteomes:UP000593571};
RN [1] {ECO:0000313|EMBL:KAF6456732.1, ECO:0000313|Proteomes:UP000593571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRouAeg1 {ECO:0000313|EMBL:KAF6456732.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF6456732.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF6456732.1}.
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DR EMBL; JACASE010000006; KAF6456732.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J8GB84; -.
DR Proteomes; UP000593571; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.10.10.60:FF:000019; Ligand-dependent corepressor isoform 1; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR21545:SF14; LIGAND-DEPENDENT COREPRESSOR; 1.
DR PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Receptor {ECO:0000313|EMBL:KAF6456732.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000593571};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 402..454
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DNA_BIND 430..450
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 74..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..110
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 54021 MW; 50B45DF61488EED3 CRC64;
MGHLVGLDEP AAEAGQEALL KQEQAKIIRF ERQAEEFLNA VFYRKDSPWV SDPNIPLVAR
EIMQRMIQQF AAEYTSKNSS TQDPSQPNST KNQSLPKASP VTTSPTAATT QNPVLSKLLM
ADQDSPLDLT VRKSQSEPSE QDGVLDLSTK KSPCAGSTSL SHSPGCSSTQ GNGRPGRPSQ
YRPDGLRSGD GVPPRSLQDG AREGFGHSTS LKVPLARSLQ ISEELLSRNQ LSTAASLGPS
GLQNHGQHLI LSREASWAKP HYEFNLSRMK FRGNGALSNI SDLPFLAENS AFPKMALQAK
QDGKKDVSHS SPVDLKIPQV RGMDLSWESR TGDQYSYSSL VMGSQTESAL SKKLRAILPK
QNRKSMLDAG PDSWGSDAEQ STSGQPYPTS DQEGDPGSKQ PRKKRGRYRQ YNSEILEEAI
SVVMSGKMSV SKAQSIYGIP HSTLEYKVKE RLGTLKNPPK KKMKLMRSEG PDVSVKIELD
PQGEAAQSAN ESKNE
//
