ID A0A7J8JKP9_ROUAE Unreviewed; 938 AA.
AC A0A7J8JKP9;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN ORFNames=HJG63_014754 {ECO:0000313|EMBL:KAF6496849.1};
OS Rousettus aegyptiacus (Egyptian fruit bat) (Pteropus aegyptiacus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea;
OC Pteropodidae; Rousettinae; Rousettus.
OX NCBI_TaxID=9407 {ECO:0000313|EMBL:KAF6496849.1, ECO:0000313|Proteomes:UP000593571};
RN [1] {ECO:0000313|EMBL:KAF6496849.1, ECO:0000313|Proteomes:UP000593571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRouAeg1 {ECO:0000313|EMBL:KAF6496849.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF6496849.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF6496849.1}.
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DR EMBL; JACASE010000002; KAF6496849.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J8JKP9; -.
DR CTD; 114880; -.
DR OrthoDB; 1854502at2759; -.
DR Proteomes; UP000593571; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0031965; C:nuclear membrane; IEA:TreeGrafter.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0015485; F:cholesterol binding; IEA:TreeGrafter.
DR GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR FunFam; 3.30.70.3490:FF:000002; Oxysterol-binding protein; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000593571};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 65..160
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 424..451
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 938 AA; 106697 MW; EA461B21353F5121 CRC64;
MHHVSLSRGN KGPSIHILER TASSGTEPSI SRQLLEPEPV SLSKEADSWE IIEGLKIGQT
NVQRPDKHEG FMLKKRKWPL KGWHKRFFVL DNGMLKYSKA PLDIQKGKVH GSIDVGLSVM
SIKKKARRID LDTEEHIYHL KVKSQDWFDA WVSKLRHHRL YRQNEIVRSP RDASFHIFPS
TSTAESSPAA NVSVVDGKVQ PNSCPWQSPL PCSNSLPATC TTGQSKVAAW LQDSEEMDRC
AEDLAHCQSN LVELSKLLQN LEILQRTQSA PNFTDMQANC VDISKKDKRV TRRWRTKSVS
KDTKIQLQEG PSVKGQFSTT RRRQRLAAAV ATTVPFSATM SPVRLHSSNP NLCADIEFQT
PPSHLTDPLE SSTDYTKLQE EFCLIAQKVH SLLKSAFNSI AIEKEKLKQM VSEQDHNKGH
STQMARLRQS LSQALNQNAE LRSRLSRIHS ESIICDQVVS VNIIPSPDEA GEQIHVSLPL
SQQVANESRL SMSESVSEFF DAQEVLLSAS SSENEASDDE SYISDVSDNI SEDNTSVADN
ISRQILNGEL TGGAFRNGRR TRLPAPCPDT SNINLWNILR NNIGKDLSKV SMPVELNEPL
NTLQHLCEEM EYSELLDKAS ETDDPYERMV LIAAFAVSGY CSTYFRAGSK PFNPVLGETY
ECIREDKGFR FFSEQVSHHP PISACHCESK NFVFWQDIRW KNKFWGKSME ILPVGTLNVM
LPKYGDFYVW NKVTTCIHNI LSGRRWIEHY GEVTIRNTKS SVCICKLTFV KVNYWNSNVN
EVQGVVMDQE GKAVHRLFGK WHEGLYCGVA PSAKCIWRPG SMPSNYELYY GFTRFAIELN
ELDPVLKDLL PPTDARFRPD QRFLEEGNLE AAAAEKQRVE ELQRSRRRYM EENNLEHIPK
FFKKVIDANQ REAWVSNDTY WELRRDPGFS KVDSPVLW
//
