ID A0A7J8JL21_ROUAE Unreviewed; 1038 AA.
AC A0A7J8JL21;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 14.
DE SubName: Full=Polyhomeotic-like protein 1 {ECO:0000313|EMBL:KAF6496995.1};
GN ORFNames=HJG63_015218 {ECO:0000313|EMBL:KAF6496995.1};
OS Rousettus aegyptiacus (Egyptian fruit bat) (Pteropus aegyptiacus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea;
OC Pteropodidae; Rousettinae; Rousettus.
OX NCBI_TaxID=9407 {ECO:0000313|EMBL:KAF6496995.1, ECO:0000313|Proteomes:UP000593571};
RN [1] {ECO:0000313|EMBL:KAF6496995.1, ECO:0000313|Proteomes:UP000593571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRouAeg1 {ECO:0000313|EMBL:KAF6496995.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF6496995.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF6496995.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JACASE010000002; KAF6496995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J8JL21; -.
DR OrthoDB; 2390104at2759; -.
DR Proteomes; UP000593571; Unassembled WGS sequence.
DR GO; GO:0035102; C:PRC1 complex; IEA:TreeGrafter.
DR GO; GO:0003682; F:chromatin binding; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042393; F:histone binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:TreeGrafter.
DR CDD; cd09577; SAM_Ph1_2_3; 1.
DR FunFam; 1.10.150.50:FF:000011; Polyhomeotic-like protein 2 isoform 1; 1.
DR FunFam; 3.30.60.160:FF:000002; Polyhomeotic-like protein 2 isoform 1; 1.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR050548; PcG_chromatin_remod_factors.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF20; POLYHOMEOTIC-LIKE PROTEIN 1; 1.
DR Pfam; PF16616; PHC2_SAM_assoc; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000593571};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 825..859
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT DOMAIN 974..1038
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 422..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..304
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..491
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..515
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..528
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 109798 MW; 72DBB8B9DEC86956 CRC64;
METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAL QALQRQPNAA QYFHQFMLQQ
QLSNAQLHSL AAVQQATIAA SRQASSPNTS TAQQQTATTQ ASINLATTSA AQLISRSQSV
SSPSATTLTQ SVLLGNTTSP PLNQSQAQMY LRPQLGNLLQ VNRTLGRNVP LASQLILMPN
GAVAAVQQEV PSAQSPGVHT DADQVQNLAV RNQQASAQGP QMQGSTQKAI PPGASPVSGL
SQASGQALAV AQASSAASGQ SLNLSQAGGG SGNSIPGSMG PGGSGQAPGG MGQLPSSGMG
GGGSCPRKGT GVVQPLPAAQ TVTVSQGSQT EAESAAAKKA EADGTGQQNV GMNLTRTATP
APSQTLISSA TYTQIQPHSL IQQQQQIHLQ QKQVVIQQQI AIHHQQQFQH RQSQLLHTAT
HLQLAQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQATALSA
PQPPQVPPTQ QVPPSQSQQQ AQTLVVQPML QSSPLSLPPD PTPKPPIPIQ SKPPGAPIKP
PQLGAAKMSA TQQPPPHIPV QVVGTRQPGT AQAQALGLAQ LAAAVPTPRG MPGTMQPGQS
HLASSSPPSS QAPGTLQECP PTLASGMTLA PVQGTAHVVK GGATTSSPVV AQVPAAFYMQ
SVHLPGKPQT LGVKRKAESE EERDDVSTMG SMLPAKASPV AESPKAMEEK SSLGEKGEPM
TNVNANAPSG ELVSLAPAPS APPPTLAMVS RQMGDSKPPQ AIVKPQILTH IIEGFVIQEG
AEPFPVGCSQ LLKESEKPLQ TGLPTGLNEN QSGGPLGGDS PSVELDKKAN LLKCEYCGKY
APAEQFRGSK RFCSMTCAKR YNVSCSHQFR LKRKKMKEFQ EVNYARARRR GPRRSSSDIA
RAKIQGKRHR GQEDSSRGSD NSSYDEALSP TSPGPLSVRA GHGERDLGNP NTAPPTPELH
GINPVFLSSN PSRWSVEEVY EFIASLQGCQ EIAEEFRSQE IDGQALLLLK EEHLMSAMNI
KLGPALKICA KINILKET
//
