ID A0A7J8JVU0_MOLMO Unreviewed; 150 AA.
AC A0A7J8JVU0;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE RecName: Full=Iron-sulfur cluster assembly 2 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00073313};
DE AltName: Full=HESB-like domain-containing protein 1 {ECO:0000256|ARBA:ARBA00077082};
GN ORFNames=HJG59_006930 {ECO:0000313|EMBL:KAF6500449.1};
OS Molossus molossus (Pallas' mastiff bat) (Vespertilio molossus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Molossidae;
OC Molossus.
OX NCBI_TaxID=27622 {ECO:0000313|EMBL:KAF6500449.1, ECO:0000313|Proteomes:UP000550707};
RN [1] {ECO:0000313|EMBL:KAF6500449.1, ECO:0000313|Proteomes:UP000550707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMolMol1 {ECO:0000313|EMBL:KAF6500449.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF6500449.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. May be
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000256|ARBA:ARBA00057540}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family.
CC {ECO:0000256|ARBA:ARBA00006718}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF6500449.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JACASF010000001; KAF6500449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J8JVU0; -.
DR Proteomes; UP000550707; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:TreeGrafter.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR FunFam; 2.60.300.12:FF:000006; Iron-sulfur cluster assembly 2 mitochondrial; 1.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000550707};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..150
FT /note="Iron-sulfur cluster assembly 2 homolog,
FT mitochondrial"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029569533"
FT DOMAIN 46..143
FT /note="FeS cluster biogenesis"
FT /evidence="ECO:0000259|Pfam:PF01521"
SQ SEQUENCE 150 AA; 16193 MW; 49840CBCE04818F4 CRC64;
MAATRSLFLT AAAVRAVTPW FLAASARPQL HREASSSSPE ACEGQVHLTD SCVQRLLEIT
QGSEFLRLEV EGGGCSGFQY RFSLDTVINP DDRIFEQGGA RVVVDSDSLA FVKGAQVDFS
QELIRSSFQV LNNPQAEKGC SCGSSFSVKL
//
