ID A0A7J9AYX4_9ROSI Unreviewed; 662 AA.
AC A0A7J9AYX4;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=Golax_023073 {ECO:0000313|EMBL:MBA0729163.1};
OS Gossypium laxum.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=34288 {ECO:0000313|EMBL:MBA0729163.1, ECO:0000313|Proteomes:UP000593574};
RN [1] {ECO:0000313|EMBL:MBA0729163.1, ECO:0000313|Proteomes:UP000593574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4 {ECO:0000313|EMBL:MBA0729163.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:MBA0729163.1};
RX PubMed=30476109;
RA Grover C.E., Arick M.A. 2nd, Thrash A., Conover J.L., Sanders W.S.,
RA Peterson D.G., Frelichowski J.E., Scheffler J.A., Scheffler B.E.,
RA Wendel J.F.;
RT "Insights into the evolution of the New World diploid cottons (Gossypium,
RT subgenus Houzingenia) based on genome sequencing.";
RL Genome Biol. Evol. 11:53-71(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBA0729163.1}.
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DR EMBL; JABEZV010428843; MBA0729163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J9AYX4; -.
DR Proteomes; UP000593574; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000593574};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 632..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..176
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 662 AA; 71724 MW; 9F1D171F6BA3DCB1 CRC64;
MESVPDLQKS MYMVVDGYPC VRLVNLSGEI GCSNPGRDKV VAPIIKYKND KELGLPSAIL
LSMDDVQGFF SRISNDSSFA SNVAGVLVES RVEIQHKLKG FSPARKFPQA EFAPYHNTTY
EWNPIGSGIM WKSYNFPVFL LSESSTSTLQ EIAMKNENTE KVYTTNVAEF DVVMQTTKVG
THDSESCLKE ETCLPLGGYR WLDQRGESFA ALDFYASICE FYVWSAVPPI NNSSSNQSKP
IILTVASMDA ASFFRDKSLG ADSPISGLIS LLAAVDALSR VDGLDNLNKQ LVFLVFTGEA
WGYLGSRRFL LELDQQSDAV RGLNSSLIQL VMEIGSTGKG FSQGNKTFFA HTQVSSDTNE
ALDALKLAQD SLKSEGVTVS NASSSNPGIP PSSLTAFLRK NSSTSGIVLE DFDTVFANKF
YHSHLDDSAN INSSAIVAAA SLVARTLYVL ASDKKDSTSS ALSSINANAS LVEELISCLL
DCDPGLSCEL VSSYITSVDT CPSHYVGVVL GEPSSTPSPN QVDDISRFVW NFLADRTSTP
KGNTTVCSKD CSNNGGVCIR AETDGKGICV TSTTRYVPAY STRLKLDSGT WKVLPPNSSD
PMGMLDPVWT ESNWNTIGLR VYTVQEAAYD RLVLLGGISV TVLAYLAIVL TRAYITKALK
QD
//
