ID A0A7J9V2X1_9MICO Unreviewed; 440 AA.
AC A0A7J9V2X1;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 20.
DE RecName: Full=DNA repair protein RadA {ECO:0000256|NCBIfam:TIGR00416, ECO:0000256|RuleBase:RU003555};
DE Flags: Fragment;
GN Name=radA {ECO:0000313|EMBL:MPV90460.1};
GN ORFNames=GB882_17440 {ECO:0000313|EMBL:MPV90460.1};
OS Georgenia ruanii.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC Bogoriellaceae; Georgenia.
OX NCBI_TaxID=348442 {ECO:0000313|EMBL:MPV90460.1, ECO:0000313|Proteomes:UP000429644};
RN [1] {ECO:0000313|EMBL:MPV90460.1, ECO:0000313|Proteomes:UP000429644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15130 {ECO:0000313|EMBL:MPV90460.1,
RC ECO:0000313|Proteomes:UP000429644};
RA Tian Z.;
RT "Georgenia wutianyii sp. nov. and Georgenia yuyongxinii sp. nov. isolated
RT from plateau pika (Ochotona curzoniae) in the Qinghai-Tibet plateau of
RT China.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase involved in processing of recombination
CC intermediates, plays a role in repairing DNA breaks. Stimulates the
CC branch migration of RecA-mediated strand transfer reactions, allowing
CC the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA
CC in the presence of ADP but not other nucleotides, has ATPase activity
CC that is stimulated by ssDNA and various branched DNA structures, but
CC inhibited by SSB. Does not have RecA's homology-searching function.
CC {ECO:0000256|RuleBase:RU003555}.
CC -!- SIMILARITY: Belongs to the RecA family. RadA subfamily.
CC {ECO:0000256|RuleBase:RU003555}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MPV90460.1}.
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DR EMBL; WHPD01003747; MPV90460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7J9V2X1; -.
DR Proteomes; UP000429644; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000725; P:recombinational repair; IEA:TreeGrafter.
DR FunFam; 3.40.50.300:FF:000050; DNA repair protein RadA; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01498; RadA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004504; DNA_repair_RadA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00416; sms; 1.
DR PANTHER; PTHR32472; DNA REPAIR PROTEIN RADA; 1.
DR PANTHER; PTHR32472:SF10; DNA REPAIR PROTEIN RADA-LIKE PROTEIN; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF13541; ChlI; 1.
DR PRINTS; PR01874; DNAREPAIRADA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003555};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003555};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003555};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003555};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003555};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003555};
KW Reference proteome {ECO:0000313|Proteomes:UP000429644};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Zinc {ECO:0000256|RuleBase:RU003555};
KW Zinc-finger {ECO:0000256|RuleBase:RU003555}.
FT DOMAIN 32..190
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:MPV90460.1"
SQ SEQUENCE 440 AA; 44645 MW; 217B85D0675A0970 CRC64;
VEEAAGTAPA RVPAALAPSA PARPIDQVAV DAARARSTGV GELDRVLGGG IVPGAVVLLA
GEPGVGKSTL LLDVAARAAA VSADVAGGGT GRPVLYVTGE ESAGQVRLRA ERIGALTPHL
LLAAETDLAT LLGHVDNADP SLLVVDSVQT IADATVDGAA GGTSQVRAVA SALIHVAKTR
DIPVLLVGHV TKDGSIAGPR VLEHLVDVVC QFEGDRHSRL RMVRAVKNRY GPTDEVGCFD
LGDTGITGLA DPSGLFLSGH RSAVPGTCVT VSLEGRRPMP TEIQALVARS PLSSPRRTTA
GLDGSRVAMT LAVLQSRLGV TLSTADVYVS TVGGARAVEP AVDLAVALAV LSAVEGKELD
PGIVAVGEVG LTGEVRTTVG VQRRLAEAAR LGFTRAIVPA RGAADLRAVP GLSVHPVDSL
REAAGAAWRA STAVVREPQH
//
