ID A0A7K4PTW8_MELMO Unreviewed; 133 AA.
AC A0A7K4PTW8;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 18.
DE SubName: Full=IGF1 factor {ECO:0000313|EMBL:NWQ51799.1};
DE Flags: Fragment;
GN Name=Igf1 {ECO:0000313|EMBL:NWQ51799.1};
GN ORFNames=MELMEL_R03575 {ECO:0000313|EMBL:NWQ51799.1};
OS Melospiza melodia (Song sparrow) (Fringilla melodia).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passerellidae; Melospiza.
OX NCBI_TaxID=44397 {ECO:0000313|EMBL:NWQ51799.1, ECO:0000313|Proteomes:UP000560247};
RN [1] {ECO:0000313|EMBL:NWQ51799.1, ECO:0000313|Proteomes:UP000560247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0008 {ECO:0000313|EMBL:NWQ51799.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWQ51799.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWQ51799.1}.
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DR EMBL; VZSA01000712; NWQ51799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K4PTW8; -.
DR Proteomes; UP000560247; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:TreeGrafter.
DR GO; GO:0008283; P:cell population proliferation; IEA:TreeGrafter.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:TreeGrafter.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:TreeGrafter.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:TreeGrafter.
DR CDD; cd04368; IlGF; 1.
DR FunFam; 1.10.100.10:FF:000001; insulin-like growth factor I isoform X1; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022350; IGF-1/2.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR022352; Ins/IGF/rlx.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR PANTHER; PTHR46845:SF1; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000560247};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..133
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029859028"
FT DOMAIN 31..89
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 95..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 34..76
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 46..89
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 75..80
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWQ51799.1"
FT NON_TER 133
FT /evidence="ECO:0000313|EMBL:NWQ51799.1"
SQ SEQUENCE 133 AA; 14836 MW; A23903FB8D3E79B8 CRC64;
QVKMHTVSYI HFFYLGLCLL TLTSSVAAGP ETLCGAELVD ALQFVCGDRG FYFSKPTGYG
SSSRRLHHKG IVDECCFQSC DLRRLEMYCA PIKPPKSARS VRAQRHTDMP KAQKVGQAGK
NSHEQPNQTN KKK
//
